Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
School of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.
ACS Appl Bio Mater. 2021 Aug 16;4(8):5908-5925. doi: 10.1021/acsabm.1c00591. Epub 2021 Jul 19.
Cancer is considered one of the leading causes of death, with a growing number of cases worldwide. However, the early diagnosis and efficient therapy of cancer have remained a critical challenge. The emergence of nanomedicine has opened up a promising window to address the drawbacks of cancer detection and treatment. A wide range of engineered nanomaterials and nanoplatforms with different shapes, sizes, and composition has been developed for various biomedical applications. Nanomaterials have been increasingly used in various applications in bioimaging, diagnosis, and therapy of cancers. Recently, numerous multifunctional and smart nanoparticles with the ability of simultaneous diagnosis and targeted cancer therapy have been reported. The multidisciplinary attempts led to the development of several exciting clinically approved nanotherapeutics. The nanobased materials and devices have also been used extensively to develop point-of-care and highly sensitive methods of cancer detection. In this review article, the most significant achievements and latest advances in the nanomaterials development for cancer nanomedicine are critically discussed. In addition, the future perspectives of this field are evaluated.
癌症被认为是主要死因之一，全球病例数量不断增加。然而，癌症的早期诊断和有效治疗仍然是一个重大挑战。纳米医学的出现为解决癌症检测和治疗的缺点开辟了一个有前途的窗口。已经开发出了具有不同形状、大小和组成的广泛的工程纳米材料和纳米平台，用于各种生物医学应用。纳米材料已越来越多地用于癌症生物成像、诊断和治疗的各种应用中。最近，已经报道了许多具有同时诊断和靶向癌症治疗能力的多功能和智能纳米粒子。多学科的尝试导致了几种令人兴奋的临床批准的纳米治疗药物的发展。基于纳米的材料和设备也被广泛用于开发即时护理和高灵敏度的癌症检测方法。在这篇综述文章中，批判性地讨论了癌症纳米医学中纳米材料开发的最重要成就和最新进展。此外，还评估了该领域的未来展望。
