人脑脊液中的2-吡咯烷酮：总γ-氨基丁酸的主要成分。
2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid.
作者信息
Haegele K D, Schwartz J J, Schoun J, Schmitt A H, Schechter P J
机构信息
Merrell Dow Research Institute, Strasbourg, France.
出版信息
J Neurochem. 1987 Nov;49(5):1402-6. doi: 10.1111/j.1471-4159.1987.tb01006.x.
Abstract
2-Pyrrolidinone, the lactam of gamma-aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was done by mass spectrometry. In lumbar CSF of four patients, 2-pyrrolidinone represented about 54% of GABA found after acid hydrolysis, thus accounting for essentially all of the hitherto unknown GABA fraction in CSF.
摘要
2-吡咯烷酮，即γ-氨基丁酸（GABA）的内酰胺，被确定为人类脑脊液中总GABA的主要成分。通过质谱法进行结构解析。在4名患者的腰椎脑脊液中，2-吡咯烷酮约占酸水解后所发现GABA的54%，因此基本上解释了脑脊液中迄今未知的所有GABA部分。
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