嗅黏膜细胞在生物打印治疗脊髓损伤中的应用前景。
Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries.
作者信息
Stepanova Olga Vladislavovna, Fursa Grigorii Andreevich, Andretsova Svetlana Sergeevna, Shishkina Valentina Sergeevna, Voronova Anastasia Denisovna, Chadin Andrey Viktorovich, Karsuntseva Ekaterina Konstantinovna, Reshetov Igor Vladimirovich, Chekhonin Vladimir Pavlovich
机构信息
Department of Basic and Applied Neurobiology, V.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russia.
Department of Neurohumoral and Immunological Research, National Medical Research Center of Cardiology, Moscow 121552, Russia.
出版信息
World J Clin Cases. 2023 Jan 16;11(2):322-331. doi: 10.12998/wjcc.v11.i2.322.
The review focuses on the most important areas of cell therapy for spinal cord injuries. Olfactory mucosa cells are promising for transplantation. Obtaining these cells is safe for patients. The use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord injuries. These cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord injuries. In addition, it is possible to increase the content of neurotrophic factors, at the site of injury, exogenously by the direct injection of neurotrophic factors or their delivery using gene therapy. The advantages of olfactory mucosa cells, in combination with neurotrophic factors, open up wide possibilities for their application in three-dimensional and four-dimensional bioprinting technology treating spinal cord injuries.
该综述聚焦于脊髓损伤细胞治疗的最重要领域。嗅黏膜细胞在移植方面颇具前景。获取这些细胞对患者而言是安全的。由于脊髓损伤后轴突的髓鞘再生和再生作用，嗅黏膜细胞的使用在恢复运动功能方面是有效的。这些细胞表达神经营养因子，其在脊髓损伤后神经组织的功能恢复中发挥重要作用。此外，通过直接注射神经营养因子或利用基因疗法进行递送，可以在外源性地增加损伤部位神经营养因子的含量。嗅黏膜细胞与神经营养因子相结合的优势，为其在治疗脊髓损伤的三维和四维生物打印技术中的应用开辟了广阔前景。
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