嗅鞘细胞移植对创伤后脊髓囊肿大小的影响。
The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts.
作者信息
Voronova A D, Stepanova O V, Chadin A V, Fursa G A, Karsuntseva E K, Valikhov M P, Semkina А S, Reshetov I V, Chekhonin V P
机构信息
V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2021 May;171(1):122-126. doi: 10.1007/s10517-021-05183-7. Epub 2021 May 28.
We studied the effect of transplantation of ensheathing cells obtained from the olfactory mucosa of rats and humans on the size of posttraumatic spinal cord cysts. MRI examination showed that transplantation of these cells into experimental posttraumatic cysts of the spinal cord led to a significant decrease in cyst volume and even their complete disappearance in two animals receiving transplantation of rat or human cells. These findings attested to regenerative processes developing as a result of ensheathing cell transplantation. Further studies in this field will be aimed at elucidation of the mechanisms underlying spinal cord regeneration in the area of posttraumatic cysts after transplantation of ensheathing cells.
我们研究了从大鼠和人类嗅黏膜获取的被膜细胞移植对创伤后脊髓囊肿大小的影响。磁共振成像（MRI）检查显示，将这些细胞移植到实验性创伤后脊髓囊肿中，会导致囊肿体积显著减小，在两只接受大鼠或人类细胞移植的动物中，囊肿甚至完全消失。这些发现证明了因被膜细胞移植而产生的再生过程。该领域的进一步研究将致力于阐明被膜细胞移植后创伤后囊肿区域脊髓再生的潜在机制。
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