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神经生长因子 3 增强细胞治疗慢性脊髓损伤的效果。

Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries.

机构信息

V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.

National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2022 May;173(1):114-118. doi: 10.1007/s10517-022-05504-4. Epub 2022 May 27.

Abstract

Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their size; neurotrophin-3 did not modulate this effect. Combined preparation of human olfactory ensheathing cells and neurotrophin- 3 can be used in neurosurgery for the treatment of patients with spinal cord injuries.

摘要

神经生长因子-3 增强人嗅鞘细胞在改善创伤性脊髓囊肿大鼠后肢运动功能中的有效性。嗅鞘细胞移植入脊髓囊肿可减小其体积;神经生长因子-3 并未调节此作用。人嗅鞘细胞和神经生长因子-3 的联合制剂可用于神经外科治疗脊髓损伤患者。

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