Department of Urology, Hamad Medical Corporation, Doha, Qatar.
Clinical Urology, Weill Cornell Medicine -Qatar, Doha, Qatar.
Front Endocrinol (Lausanne). 2023 Jan 4;13:1050441. doi: 10.3389/fendo.2022.1050441. eCollection 2022.
Metabolic Age (MetAge) and body composition analysis may reflect an individual's metabolic status, which is believed to influence male sexual and gonadal functions. Although erectile dysfunction (ED) and hypogonadism are increasingly prevalent with age, they are also detected among younger men. This study aims to assess the impact of MetAge and body composition on male sexual and gonadal status overall, and particularly in men younger than 40 years of age.
This was a cross-sectional study of 90 male healthcare workers, between the ages of 18-55, randomly selected based on their corporation numbers. In addition to Bioelectric Impedance Analysis, subjects were requested to fill the International Index of Erectile Function questionnaire (IIEF-5) and to provide an early morning serum testosterone (T) sample.
The mean participants' age was 39.4 ± 9.4 years, MetAge was 45.54 ± 10.35 years, serum T level was 13.68 ± 4.49 nmol/L and BMI was 28.8 ± 4.7 kg/m. Significant negative correlations were obtained between serum T, MetAge, body weight and fat composition. Significant negative correlations between the IIEF-5 score, MetAge, and fat composition, were only reported in subjects <40 years of age. Significantly lower T levels (p=0.002), significantly older MetAge (p=0.034), and higher BMI (p=0.044) and degree of obesity (p=0.042) were observed in participants <40 years with erectile dysfunction (ED) compared to their counterparts without ED.
MetAge and body composition parameters significantly impact the androgenic state. ED in men <40 years is associated with lower T levels, older MetAge and higher BMI and degree of obesity.
代谢年龄（MetAge）和身体成分分析可以反映个体的代谢状态，据信这会影响男性的性和性腺功能。尽管勃起功能障碍（ED）和性腺功能减退症随着年龄的增长而越来越普遍，但也会在年轻男性中发现。本研究旨在评估代谢年龄和身体成分对男性整体性功能和性腺功能的影响，特别是在年龄小于 40 岁的男性中。
这是一项横断面研究，共纳入 90 名年龄在 18-55 岁之间的男性医疗保健工作者，根据其公司编号随机选择。除了生物电阻抗分析外，还要求受试者填写国际勃起功能指数问卷（IIEF-5）并提供清晨血清睾酮（T）样本。
参与者的平均年龄为 39.4±9.4 岁，代谢年龄为 45.54±10.35 岁，血清 T 水平为 13.68±4.49nmol/L，BMI 为 28.8±4.7kg/m2。血清 T、代谢年龄、体重和脂肪成分之间存在显著的负相关。仅在年龄小于 40 岁的受试者中报告了 IIEF-5 评分、代谢年龄和脂肪成分之间的显著负相关。与无 ED 的受试者相比，年龄小于 40 岁的 ED 患者的 T 水平显著较低（p=0.002），代谢年龄显著较大（p=0.034），BMI 和肥胖程度更高（p=0.044）。
代谢年龄和身体成分参数显著影响雄激素状态。年龄小于 40 岁的男性 ED 与较低的 T 水平、较大的代谢年龄、较高的 BMI 和肥胖程度有关。
