Ramírez-Gallegos Ignacio, Tárraga López Pedro Juan, Paublini Oliveira Hernán, López-González Ángel Arturo, Martorell Sánchez Cristina, Martínez-Almoyna-Rifá Emilio, Ramírez-Manent José Ignacio
ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07120 Palma, Balearic Islands, Spain.
Faculty of Medicine, University of Castilla la Mancha, 02071 Albacete, Castilla-La Mancha, Spain.
Nutrients. 2025 Mar 8;17(6):945. doi: 10.3390/nu17060945.
Metabolic age (MA) is the difference between an individual's actual age and the age of their body based on physiological and biological factors. It is an indicator that reflects a person's physical and biological state, regardless of chronological age. Insulin resistance (IR) is a health disorder in which tissues exhibit a reduced response to the circulating glucose uptake stimulated by insulin. The aim of this study is to evaluate the association between MA, determined through bioelectrical impedance analysis, and the risk of IR, assessed using validated scales, in a cohort of Spanish workers. A descriptive cross-sectional study was conducted on 8590 Spanish workers to assess the association between MA and a set of sociodemographic variables, health habits, and IR risk scales such as the Triglyceride-Glucose Index (TyG Index), Metabolic Score for Insulin Resistance (METS-IR), and Single Point Insulin Sensitivity Estimator (SPISE). All analyzed variables were associated with MA values, with the strongest associations observed for IR risk scale values (OR 4.88 [95% CI 4.12-5.65] for METS-IR, 4.42 [95% CI 3.70-5.15] for SPISE, and 3.42 [95% CI 2.97-3.87] for the TyG Index) and physical activity. Metabolic age is influenced by sociodemographic variables such as age, sex, and social class; health habits such as smoking, physical activity, and adherence to the Mediterranean diet; and by IR risk scale values.
代谢年龄（MA）是个体实际年龄与基于生理和生物学因素的身体年龄之间的差值。它是一个反映人的身体和生物学状态的指标，与实际年龄无关。胰岛素抵抗（IR）是一种健康紊乱状况，即组织对胰岛素刺激的循环葡萄糖摄取反应降低。本研究的目的是在一组西班牙工人中，评估通过生物电阻抗分析确定的代谢年龄与使用经过验证的量表评估的胰岛素抵抗风险之间的关联。对8590名西班牙工人进行了一项描述性横断面研究，以评估代谢年龄与一系列社会人口统计学变量、健康习惯以及胰岛素抵抗风险量表（如甘油三酯 - 葡萄糖指数（TyG指数）、胰岛素抵抗代谢评分（METS - IR）和单点胰岛素敏感性估计值（SPISE））之间的关联。所有分析的变量均与代谢年龄值相关，其中胰岛素抵抗风险量表值（METS - IR的比值比为4.88 [95%可信区间4.12 - 5.65]，SPISE为4.42 [95%可信区间3.70 - 5.15]，TyG指数为3.42 [95%可信区间2.97 - 3.87]）和身体活动与代谢年龄的关联最强。代谢年龄受年龄、性别和社会阶层等社会人口统计学变量；吸烟、身体活动和坚持地中海饮食等健康习惯；以及胰岛素抵抗风险量表值的影响。
