Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
State Key Laboratory for Chemistry and Molecular Engineering of Medical Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.
Front Endocrinol (Lausanne). 2023 Jan 4;13:1077514. doi: 10.3389/fendo.2022.1077514. eCollection 2022.
Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging. The neurokinin 1 receptor (NK1R) inhibitor, aprepitant has been broadly applied for an antidepressant effect in depressive patients. Recent literature has indicated a therapeutic effect of downregulation in NK1R to diabetes-related fracture, cardiomyopathy, gastroparesis, and ocular surface disorders. In this study, differential expression genes in diabetes and depression were analyzed based on several RNA sequencing datasets from the GEO database to confirm NK1R in the overlapping set. Interaction network and gene set enrichment analysis were subsequently conducted. As a result, NK1R-related genes took part in angiogenesis, epithelial-mesenchymal transition (EMT), collagen deposition, and inflammation in diabetes and depression. , the downregulation of NK1R was proved to promote vascular proliferation and enhance diabetic wound healing, which provides a potential therapeutic target for the management of diabetic non-healing wounds and depression.
糖尿病是一种全球性疾病，由于其并发症对患者有巨大影响，其中非愈合性伤口和抑郁是常见且具有挑战性的。神经激肽 1 受体（NK1R）抑制剂阿瑞匹坦已广泛应用于抑郁症患者的抗抑郁作用。最近的文献表明，下调 NK1R 对糖尿病相关骨折、心肌病、胃轻瘫和眼表疾病具有治疗作用。在这项研究中，基于 GEO 数据库中的几个 RNA 测序数据集分析了糖尿病和抑郁症中的差异表达基因，以确认重叠集中的 NK1R。随后进行了互作网络和基因集富集分析。结果表明，NK1R 相关基因参与了糖尿病和抑郁症中的血管生成、上皮-间充质转化（EMT）、胶原沉积和炎症。此外，下调 NK1R 被证明可促进血管增殖并增强糖尿病性伤口愈合，这为糖尿病性非愈合性伤口和抑郁症的治疗提供了一个潜在的治疗靶点。
