使用 Kirby Bauer 方法对 Septilin 和三果汤的草药制剂与传统 2%氯己定在根管和口腔共生细菌上的抗菌效果进行比较评估：一项研究。

Comparative Evaluation of Antimicrobial Efficacy of Herbal Formulations of Septilin and Triphala with Conventional 2% Chlorhexidine on Root Canal and Oral Commensal Bacteria using Kirby Bauer Method: An Study.

作者信息

Ahmed Shadab, Shahnawaz Kamil, Mandal Tapan Kumar, Ghafir Mamnoon, Gummaluri Shiva Shankar, Vishal Gaurav

机构信息

Department of Conservative Dentistry and Endodontics, Sri Siddhartha Dental College and Hospital, Tumakuru, Karnataka, India.

Department of Conservative Dentistry and Endodontics, Community Health Centre, Munger, Bihar, India.

出版信息

Contemp Clin Dent. 2022 Oct-Dec;13(4):383-388. doi: 10.4103/ccd.ccd_423_21. Epub 2022 Nov 8.

DOI:10.4103/ccd.ccd_423_21

PMID:36686996

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9855254/

Abstract

BACKGROUND

Endodontic flareups are always very difficult to treat because of reasons like drug resistance previously sodium hypochlorite and chlorhexidine have been used in the literature but with advancements newer materials like herbal products have been tried for this purpose. Thus, present vitro study was conducted to comparatively evaluate the efficacy of herbal formulations on commensals of oral cavity and root canal.

MATERIALS AND METHODS

In this study antimicrobial efficacy of chlorhexidine 2%, Septilin and Triphala wer evaluated with the help of Kirby Bauer test. The microorganisms used were and . The samples were placed in standardized wells and were subjected to incubation. Subsequently zones of inhibition were measured with the help of a caliper. One-factor analysis of variance, Tukey's least significant difference test and Student's independent -test were performed to find a significant difference ( < 0.05) in the two groups.

RESULTS

For chlorhexidine in mean antibacterial efficacy was 11.10 ± 1.25 and in 10.0 ± 1.33. The value for was lesser in Triphala with a value of 10.35 ± 1.63 and in mean value was 9.05 ± 1.27. For Septilin the mean for was 10.40 ± 1.04, and the mean antibacterial efficacy in was 9.65 ± 1.38.

CONCLUSION

Septilin and Triphala showed remarkable efficacy concerning zones of inhibition. These herbal formulations have tremendous potential to be used as adjuncts to traditional disinfection modalities though it has scope of further research.

摘要

背景

由于耐药性等原因，牙髓病急性发作总是很难治疗。以前文献中曾使用过次氯酸钠和氯己定，但随着技术进步，人们尝试了像草药产品这样的新材料来治疗牙髓病急性发作。因此，本体外研究旨在比较评估草药配方对口腔共生菌和根管的疗效。

材料与方法

在本研究中，借助 Kirby Bauer 试验评估了 2%氯己定、Septilin 和三果汤的抗菌效果。使用的微生物为[此处原文缺失微生物名称]。将样本置于标准化孔中并进行培养。随后用卡尺测量抑菌圈。进行单因素方差分析、Tukey 最小显著差异检验和学生独立 t 检验，以找出两组之间的显著差异（P < 0.05）。

结果

对于氯己定，在[此处原文缺失相关分组信息]中的平均抗菌效果为 11.10 ± 1.25，在[此处原文缺失相关分组信息]中为 10.0 ± 1.33。三果汤在[此处原文缺失相关分组信息]中的值较小，为 10.35 ± 1.63，在[此处原文缺失相关分组信息]中的平均值为 9.05 ± 1.27。对于 Septilin，在[此处原文缺失相关分组信息]中的平均值为 10.40 ± 1.04，在[此处原文缺失相关分组信息]中的平均抗菌效果为 9.65 ± 1.38。