Du Fang-Zhi, Zhang Xu, Zhang Rui-Li, Wang Qian-Qiu
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for STD Control, China Centers for Disease Control and Prevention, Nanjing, China.
Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Med (Lausanne). 2023 Jan 6;9:1040133. doi: 10.3389/fmed.2022.1040133. eCollection 2022.
Neurosyphilis is a major clinical manifestation of syphilis. In recent years, an increase in neurosyphilis cases has been reported in many countries. The overall incidence of neurosyphilis remains unknown, and there is a lack of understanding of the disease pathogenesis, which hampers clinical management, development of prevention strategies, and control. This article proposes the CARE-NS research strategy to enhance the clinical management of neurosyphilis, which consists of six key features: comprehensive management including multidisciplinary treatment (C), alleviating neurological impairment and sequelae (A), risk factors and clinical epidemiology (R), etiology and pathogenesis (E), new diagnostic indicators and strategies (N), and social impact and cost-effectiveness analysis (S).
神经梅毒是梅毒的一种主要临床表现。近年来，许多国家都报告了神经梅毒病例的增加。神经梅毒的总体发病率仍然未知，并且对该疾病的发病机制缺乏了解，这阻碍了临床管理、预防策略的制定和控制。本文提出了CARE-NS研究策略以加强神经梅毒的临床管理，该策略包括六个关键特征：综合管理，包括多学科治疗（C）、减轻神经损伤和后遗症（A）、危险因素和临床流行病学（R）、病因和发病机制（E）、新的诊断指标和策略（N）以及社会影响和成本效益分析（S）。
