Jain Ashish, Chowdhury Nilotpal, Jain Sanchit, Uttam Nikita, Meinia Sushant Kumar
1Department of Transfusion Medicine and Blood Bank, All India Institute of Medical Sciences, Rishikesh, Uttrakhand 249201 India.
2Department of Pathology and Laboratory Medicine and Blood Bank Incharge, All India Institute of Medical Sciences, Rishikesh, India.
Indian J Hematol Blood Transfus. 2018 Oct;34(4):666-670. doi: 10.1007/s12288-018-0954-9. Epub 2018 Apr 3.
Subclinical Iron deficiency appearing in blood donors after blood donation is a recognized problem. Donors at an increased risk of iron deficiency need to be identified. Blood donors meeting national selection criteria were included in the study. Complete blood counts were done using Sysmex XP-100 three part hematology analyzer. Differences in RBC indices among donor groups defined by previous donations were then analyzed statistically. Six hundred and seventy three males and ninety six females were studied. In males, Kruskal-Wallis test showed significant differences between groups defined by number of donations for MCH and MCV ( value < 0.001), but not for MCHC ( value = 0.09) and RDW ( value = 0.6). Post-hoc tests showed statistically significant difference between donors having six or more donations compared to donors having no previous donations for both MCH as well as MCV. No significant difference was found between donor subgroups in females for any of the indices; however, no female donated blood more than three times in the study. There is increased risk for iron deficiency in donors having six or more previous donations, and evidence for starting an iron screening and supplementation programme for these donors.
献血后献血者出现亚临床缺铁是一个公认的问题。需要识别缺铁风险增加的献血者。符合国家筛选标准的献血者被纳入研究。使用Sysmex XP - 100三分群血液分析仪进行全血细胞计数。然后对根据既往献血情况定义的献血者组之间的红细胞指数差异进行统计学分析。共研究了673名男性和96名女性。在男性中，Kruskal - Wallis检验显示，按献血次数定义的组之间，平均红细胞血红蛋白含量（MCH）和平均红细胞体积（MCV）存在显著差异（P值<0.001），但平均红细胞血红蛋白浓度（MCHC）（P值 = 0.09）和红细胞分布宽度（RDW）（P值 = 0.6）无显著差异。事后检验显示，与从未献血者相比，献血6次或更多次的献血者在MCH和MCV方面均存在统计学显著差异。在女性中，各亚组之间的任何指标均未发现显著差异；然而，在该研究中没有女性献血超过3次。既往献血6次或更多次的献血者缺铁风险增加，有证据表明应为这些献血者启动铁筛查和补充计划。
