Bahn M M, Landaw E M
Department of Biomathematics, UCLA School of Medicine 90024.
J Pharmacokinet Biopharm. 1987 Jun;15(3):255-69. doi: 10.1007/BF01066321.
The single-point dose prediction method is based on the observation that for drugs obeying single compartment elimination kinetics there is a nearly constant reciprocal relation between the plasma level at a fixed time following a single loading dose and the dose that is required to maintain the desired steady state plasma level of the drug. This paper describes an improved method for choosing a plasma sampling time and a proportionality constant. It applies to either drugs administered intravenously or to drugs whose rates of absorption from the site of administration are very rapid compared to their rates of elimination from the body. The sampling time and proportionality constant chosen are those that minimize the maximum relative deviation of the maintenance dose estimated by the single-point method from the dose that would be estimated if the individual's true elimination rate constant were known. The paper also supplies a method to determine the maximum error that may be introduced into the estimation of the maintenance dose by using the single-point method.
对于遵循单室消除动力学的药物，单次负荷剂量后在固定时间的血浆水平与维持药物所需稳态血浆水平所需剂量之间存在近乎恒定的倒数关系。本文描述了一种选择血浆采样时间和比例常数的改进方法。它适用于静脉给药的药物，或与从体内消除的速率相比，从给药部位吸收速率非常快的药物。所选择的采样时间和比例常数是使单点法估计的维持剂量与已知个体真实消除速率常数时估计的剂量之间的最大相对偏差最小化的时间和常数。本文还提供了一种方法，用于确定使用单点法估计维持剂量时可能引入的最大误差。
