饮食炎症指数与认知障碍之间的关联：一项荟萃分析。
Association between dietary inflammatory index and cognitive impairment: A meta-analysis.
作者信息
Jia Yuxi, Yan Shoumeng, Sun Mengzi, Yang Yixue, Wang Ling, Wu Caihong, Li Ping
机构信息
Application Demonstration Center of Precision Medicine Molecular Diagnosis, The Second Hospital of Jilin University, Changchun, China.
Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China.
出版信息
Front Aging Neurosci. 2023 Jan 4;14:1007629. doi: 10.3389/fnagi.2022.1007629. eCollection 2022.
AIMS
Cognitive impairment is an increasingly urgent global public health challenge. Dietary Inflammatory Index (DII) is a literature-derived score that links diet to inflammation. The relationship between DII and cognitive impairment remains controversial. Therefore, our study aimed to analysis the role of DII on the risk of cognitive impairment by meta-analysis.
METHODS
PubMed, Cochrane Library, MEDLINE, Web of Science and EMBASE databases were searched up to July 2022. Newcastle-Ottawa scale (NOS) and Joanna Briggs Institute (JBI) Checklist were performed to estimate the quality of studies.
RESULTS
Nine observational studies with 19,379 subjects were included. Our study found that higher DII could elevate the risk of cognitive impairment (OR = 1.46, 95%CI = 1.26, 1.69). Meanwhile, the OR of cognitive impairment was 1.49 (95%CI = 1.21, 1.83) for cross-sectional studies and 1.42 (95%CI = 1.12, 1.79) for cohort studies, respectively.
CONCLUSION
Our meta-analysis indicated that higher DII (indicating a more pro-inflammatory diet) is related to increased risk of cognitive impairment.
目的
认知障碍是一个日益紧迫的全球公共卫生挑战。饮食炎症指数（DII）是一种从文献中得出的将饮食与炎症联系起来的评分。DII与认知障碍之间的关系仍存在争议。因此，我们的研究旨在通过荟萃分析来分析DII在认知障碍风险中的作用。
方法
检索截至2022年7月的PubMed、Cochrane图书馆、MEDLINE、Web of Science和EMBASE数据库。采用纽卡斯尔-渥太华量表（NOS）和乔安娜·布里格斯研究所（JBI）清单来评估研究质量。
结果
纳入了9项观察性研究，共19379名受试者。我们的研究发现，较高的DII会增加认知障碍的风险（OR = 1.46，95%CI = 1.26，1.69）。同时，横断面研究中认知障碍的OR为1.49（95%CI = 1.21，1.83），队列研究中为1.42（95%CI = 1.12，1.79）。
结论
我们的荟萃分析表明，较高的DII（表明饮食更具促炎作用）与认知障碍风险增加有关。
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