Telfer E, Gosden R G
Department of Physiology, University Medical School, Edinburgh, U.K.
J Reprod Fertil. 1987 Sep;81(1):137-47. doi: 10.1530/jrf.0.0810137.
The incidence of polyovular types in the growing follicle population was estimated using quantitative cytology. Of 15 species studied, polyovular follicles were recorded in the following species and in ascending order of abundance: rabbits, rhesus monkeys, humans, cats, dogs. The incidence in bitches was 14% in animals aged 1-2 years but only 5% at 7-11 years old. The frequency of the various types of polyovular preantral follicle varied inversely with the numbers of oocytes per follicle and the probability of finding a follicle with more than 5 oocytes was remote. In young ovaries the frequency was constant in the early stages of growth but decreased in the largest preantral stage. The pattern in ageing ovaries was, by contrast, one of declining frequency such that few if any polyovular types completed development. The ovary of the ageing bitch was also characterized by a higher incidence of degenerating follicles and a much smaller pool of primordial stages. Polyovular follicles were larger than uniovular types at comparable stages which were defined by the number of granulosa cell layers. Their oocytes were smaller but the overall ooplasmic mass was increased with a corresponding increase in the mass of granulosa cells.
使用定量细胞学方法估计生长卵泡群体中多卵型的发生率。在所研究的15个物种中，记录到多卵卵泡的物种如下，按丰度升序排列：兔子、恒河猴、人类、猫、狗。1至2岁母犬的发生率为14%，而7至11岁时仅为5%。不同类型多卵前卵泡的频率与每个卵泡中的卵母细胞数量呈反比，找到一个有超过5个卵母细胞的卵泡的概率很小。在年轻卵巢中，频率在生长早期是恒定的，但在最大的前卵泡阶段会下降。相比之下，老龄卵巢中的模式是频率下降，以至于很少有多卵型卵泡完成发育。老龄母犬的卵巢还具有退化卵泡发生率较高和原始卵泡池小得多的特点。在由颗粒细胞层数定义的可比阶段，多卵卵泡比单卵卵泡大。它们的卵母细胞较小，但总体卵质质量增加，颗粒细胞质量相应增加。
