青少年时期睡眠不足与多发性硬化症风险：来自瑞典病例对照研究的结果。
Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study.
机构信息
Stress Research, Stockholm University, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Neurol Neurosurg Psychiatry. 2023 May;94(5):331-336. doi: 10.1136/jnnp-2022-330123. Epub 2023 Jan 23.
BACKGROUND
Shift work, which often results in sleep deprivation and circadian desynchrony, has been associated with increased risk of multiple sclerosis (MS). We aimed at studying the impact of sleep duration, circadian disruption and sleep quality on MS risk.
METHODS
We used a Swedish population-based case-control study (2075 cases, 3164 controls). Aspects of sleep were associated with MS risk by calculating OR with 95% CIs using logistic regression models.
RESULTS
Compared with sleeping 7-9 hours/night during adolescence, short sleep (<7 hours/night) was associated with increased risk of developing MS (OR 1.4, 95% OR 1.1-1.7). Similarly, subjective low sleep quality during adolescence increased the risk of subsequently developing MS (OR 1.5, 95% CI 1.3 to 1.9), whereas phase shift did not significantly influence the risk. Our findings remained similar when those who worked shifts were excluded.
CONCLUSIONS
Insufficient sleep and low sleep quality during adolescence seem to increase the risk of subsequently developing MS. Sufficient restorative sleep at young age, needed for adequate immune functioning, may be a preventive factor against MS.
背景
轮班工作通常会导致睡眠不足和昼夜节律紊乱，与多发性硬化症（MS）的风险增加有关。我们旨在研究睡眠持续时间、昼夜节律紊乱和睡眠质量对 MS 风险的影响。
方法
我们使用了一项基于瑞典人群的病例对照研究（2075 例病例，3164 例对照）。通过使用逻辑回归模型计算 OR 和 95%置信区间，研究了睡眠各个方面与 MS 风险的相关性。
结果
与青少年时期每晚睡眠 7-9 小时相比，睡眠不足（<7 小时/晚）会增加患 MS 的风险（OR 1.4，95%OR 1.1-1.7）。同样，青少年时期主观睡眠质量差也会增加随后患 MS 的风险（OR 1.5，95%CI 1.3-1.9），而相位偏移则不会显著影响风险。当排除轮班工作者后，我们的发现仍然相似。
结论
青少年时期睡眠不足和睡眠质量差似乎会增加随后患 MS 的风险。年轻时充足的恢复性睡眠对于适当的免疫功能可能是预防 MS 的一个因素。
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