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胚胎植入前遗传学检测后的非整倍体筛查:对医生知识和实践的全国性调查。

Aneuploidy screening after preimplantation genetic testing: a national survey of physician knowledge and practice.

机构信息

Department of Obstetrics and Gynecology, Stamford Hospital, 1 Hospital Plaza, Stamford, CT, 06902, USA.

出版信息

J Assist Reprod Genet. 2023 Mar;40(3):665-669. doi: 10.1007/s10815-023-02716-z. Epub 2023 Jan 24.

Abstract

PURPOSE

To assess the knowledge of generalist OB/GYN providers on aneuploidy screening recommendations for patients who utilized preimplantation genetic testing, and to survey providers' current practice habits.

METHODS

A 12-question survey was distributed by email to OB/GYN physicians in the USA. Demographic information was also collected.

RESULTS

A total of 178 survey responses were included for analysis. Sixty-seven percent correctly identified the current ACOG recommendation to offer additional aneuploidy screening/invasive diagnostic testing regardless of PGT status, and 66% said their practice is consistent with this recommendation. Ninety-one percent of responders correctly answered that in vitro fertilization does not always include PGT and 63% of responders were able to correctly identify the 3 available types of PGT. Thirty-three percent (n = 58) were attending physicians, and 67% (n = 120) were resident physicians. Most participants (81%, n = 145) stated they have been in practice 0-9 years, and the remaining 19% (n = 33) stated they have been in practice ≥ 10 years.

CONCLUSION

Significant knowledge gaps of PGT and aneuploidy screening recommendations after PGT exist among generalist OB/GYN physicians. Efforts should be made to educate providers on the importance of offering aneuploidy screening and diagnostic testing to patients who utilized PGT to improve patient care.

摘要

目的

评估普通妇产科医生对接受植入前遗传学检测(PGT)患者的非整倍体筛查建议的了解程度,并调查提供者的当前实践习惯。

方法

通过电子邮件向美国的妇产科医生分发了一份 12 个问题的调查。还收集了人口统计学信息。

结果

共纳入 178 份调查回复进行分析。67%的人正确识别了当前 ACOG 的建议,即无论 PGT 状态如何,都应提供额外的非整倍体筛查/侵入性诊断性检测,66%的人表示他们的实践符合这一建议。91%的应答者正确回答体外受精并不总是包括 PGT,63%的应答者能够正确识别 3 种可用的 PGT 类型。33%(n=58)为主治医生,67%(n=120)为住院医生。大多数参与者(81%,n=145)表示他们的从业年限为 0-9 年,其余 19%(n=33)表示他们的从业年限≥10 年。

结论

普通妇产科医生对 PGT 和 PGT 后非整倍体筛查建议存在明显的知识差距。应努力教育提供者为接受 PGT 的患者提供非整倍体筛查和诊断性检测的重要性,以改善患者护理。

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Utilization of preimplantation genetic testing in the USA.美国的胚胎植入前遗传学检测的应用。
J Assist Reprod Genet. 2021 May;38(5):1045-1053. doi: 10.1007/s10815-021-02078-4. Epub 2021 Apr 26.
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Practice Bulletin No. 163: Screening for Fetal Aneuploidy.实践通报第 163 号:胎儿非整倍体筛查。
Obstet Gynecol. 2016 May;127(5):e123-e137. doi: 10.1097/AOG.0000000000001406.

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