Regensburg Department of Public Health, Altmühlstr. 3, 93059, Regensburg, Germany.
Department of Epidemiology and Preventive Medicine, Faculty of Medicine, University of Regensburg, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Infection. 2023 Aug;51(4):1147-1152. doi: 10.1007/s15010-023-01982-4. Epub 2023 Jan 24.
The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has caused substantial mortality worldwide. We investigated clinical and demographic features of COVID-19-related deaths that occurred between March 2020 and January 2022 in Regensburg, Germany.
We compared data across four consecutive time periods: March 2020 to September 2020 (period 1), October 2020 to February 2021 (period 2), March 2021 to August 2021 (period 3), and September 2021 to January 2022 (period 4).
Overall, 405 deaths in relation to COVID-19 were reported. The raw case fatality ratio (CFR) was 0.92. In periods 1 to 4, the CFRs were 1.70%, 2.67%, 1.06%, and 0.36%. The age-specific CFR and mortality were highest in persons aged ≥ 80 years in period 2 while mortality in younger cases increased with time. The median age at death was 84 years and it varied slightly across periods. Around 50% of cases of death were previously hospitalized. In all time periods, the cause of death was mostly attributed to COVID-19. Over the four periods, we did not find significant changes in the distribution of sex and risk factors for severe disease. The most frequent risk factor was cardio-circulatory disease.
In conclusion, the CFR decreased over time, most prominently for period 4. Mortality was considerable and younger cases were increasingly at risk.
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）在全球范围内造成了大量死亡。我们调查了 2020 年 3 月至 2022 年 1 月期间在德国雷根斯堡发生的与 COVID-19 相关的死亡的临床和人口统计学特征。
我们比较了四个连续时间段的数据：2020 年 3 月至 2020 年 9 月（第 1 期）、2020 年 10 月至 2021 年 2 月（第 2 期）、2021 年 3 月至 2021 年 8 月（第 3 期）和 2021 年 9 月至 2022 年 1 月（第 4 期）。
总体而言，报告了与 COVID-19 相关的 405 例死亡。原始病死率（CFR）为 0.92。在第 1 至 4 期，CFR 分别为 1.70%、2.67%、1.06%和 0.36%。第 2 期年龄特异性 CFR 和死亡率在≥80 岁人群中最高，而年轻病例的死亡率随时间增加。死亡的中位年龄为 84 岁，各期略有差异。约 50%的死亡病例之前曾住院治疗。在所有时间段，死亡的主要原因均归因于 COVID-19。在四个时期，我们没有发现性别和严重疾病风险因素的分布有显著变化。最常见的危险因素是心血管疾病。
总之，CFR 随时间降低，尤其是第 4 期。死亡率相当高，年轻病例的风险越来越大。
