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无乳链球菌菌血症的主要危险因素：一项基于人群的研究。

Major risk factors for Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study.

机构信息

Department of Internal Medicine, Tampere University Hospital, Elämänaukio, Kuntokatu 2, 33520, Tampere, Finland.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

出版信息

BMC Infect Dis. 2023 Jan 23;23(1):43. doi: 10.1186/s12879-023-07992-9.

DOI:10.1186/s12879-023-07992-9
PMID:36690934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9869575/
Abstract

BACKGROUND

Streptococcus dysgalactiae subspecies equisimilis is a human pathogen causing severe invasive infections. Detailed information on S. dysgalactiae subsp. equisimilis bacteremia and especially of predisposing factors are lacking. The purpose of the study is to investigate the risk factors of S. dysgalactiae subsp. equisimilis bacteremia compared to the general population in Finland.

METHODS

We retrospectively reviewed all patients older than 18 years with S. dysgalactiae subsp. equisimilis bacteremia in the Pirkanmaa health district from August 2015 to July 2018. The risk factors for S. dysgalactiae subsp. equisimilis bacteremia were investigated with respect to the normal population in Finland using the Finhealth study data provided by the Finnish institute for health and welfare. The study group was matched with the Finhealth study by age and sex.

RESULTS

Altogether 230 cases of S. dysgalactiae subsp. equisimilis bacteremia were detected. The medical records of 217 episodes of S. dysgalactiae subsp. equisimilis bacteremia (involving 211 patients) were available for analysis. Obesity was a statistically significant risk factor for S. dysgalactiae subsp. equisimilis bacteremia (Odds Ratio 2.96 [95% CI 2.22-3.96]). Diabetes and coronary artery disease were also associated with an increased risk of S. dysgalactiae subsp. equisimilis bacteremia (OR 4.82 [95% CI 3.62-6.42]) and (OR 3.03 [95% CI 2.18-4.19]).

CONCLUSIONS

We found obesity, diabetes, and coronary artery disease to be associated with an increased risk for S. dysgalactiae subsp. equisimilis bacteremia. These results provide an increased understanding of risk factors for S. dysgalactiae subsp. equisimilis bacteremia.

摘要

背景

马链球菌兽亚种是一种人类病原体，可引起严重的侵袭性感染。关于马链球菌兽亚种菌血症的详细信息，特别是其诱发因素的信息尚不清楚。本研究的目的是调查与芬兰普通人群相比，马链球菌兽亚种菌血症的危险因素。

方法

我们回顾性分析了 2015 年 8 月至 2018 年 7 月皮卡拉区年龄大于 18 岁的马链球菌兽亚种菌血症患者。利用芬兰国家健康与福利研究所提供的芬兰健康研究数据，调查了马链球菌兽亚种菌血症的危险因素。研究组按年龄和性别与芬兰健康研究进行匹配。

结果

共发现 230 例马链球菌兽亚种菌血症。有 217 例马链球菌兽亚种菌血症（涉及 211 例患者）的病历可用于分析。肥胖是马链球菌兽亚种菌血症的一个统计学上显著的危险因素（优势比 2.96 [95%置信区间 2.22-3.96]）。糖尿病和冠状动脉疾病也与马链球菌兽亚种菌血症的风险增加相关（OR 4.82 [95% CI 3.62-6.42]）和（OR 3.03 [95% CI 2.18-4.19]）。

结论

我们发现肥胖、糖尿病和冠状动脉疾病与马链球菌兽亚种菌血症的风险增加相关。这些结果增加了对马链球菌兽亚种菌血症危险因素的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2a/9869575/41bdb2d4f327/12879_2023_7992_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2a/9869575/41bdb2d4f327/12879_2023_7992_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2a/9869575/41bdb2d4f327/12879_2023_7992_Fig1_HTML.jpg

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