Department of Internal Medicine, Tampere University Hospital, Elämänaukio, Kuntokatu 2, 33520, Tampere, Finland.
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Eur J Clin Microbiol Infect Dis. 2023 Jul;42(7):819-825. doi: 10.1007/s10096-023-04607-8. Epub 2023 Apr 29.
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a human pathogen causing severe invasive infections. Population-based studies on SDSE bacteremia are limited. The purpose of this study was to investigate the incidence, seasonal pattern, clinical manifestations, and recurrence of SDSE bacteraemia. Records regarding patients aged ≥ 18 years with SDSE bacteremia in the Pirkanmaa health district in August 2015 to July 2018 were retrospectively reviewed. A total of 230 SDSE bacteremia episodes were identified, with 217 episodes (involving 211 patients) available for analysis. The mean annual incidence rate of SDSE bacteremia was 16.9/100 000 inhabitants. Most episodes (33%) were detected in the summer (June to August) (p = 0.058). Episodes with bacteremic cellulitis were statistically significantly more common during the summer compared with other seasons (p = 0.008). Cellulitis was the most common presenting clinical manifestation of SDSE bacteremia (68% of all episodes). Risk factors of recurring bacteremia were chronic eczema and/or skin erosion (OR 3.96 [95% CI 1.11-14.1]), heart disease (OR 3.56 [95% CI 1.22-10.4]), diabetes (OR 3.77 [95% CI 1.35-10.5]) and a history of cellulitis. We found a remarkably high incidence of SDSE bacteraemia in the Pirkanmaa health district. Bacteraemic cellulitis, which was the predominant clinical manifestation is more often occurred in the summer. Risk factors of recurring SDSE bacteremia were a history of cellulitis, chronic eczema or skin erosion, diabetes, and heart disease.
无乳链球菌（SDSE）是人畜共患病原体，可引起严重的侵袭性感染。基于人群的 SDSE 菌血症研究有限。本研究旨在调查 SDSE 菌血症的发病率、季节性模式、临床表现和复发情况。回顾了 2015 年 8 月至 2018 年 7 月在皮尔卡区年龄≥18 岁的 SDSE 菌血症患者的记录。共确定了 230 例 SDSE 菌血症发作，其中 217 例（涉及 211 例患者）可用于分析。SDSE 菌血症的年平均发病率为 16.9/100000 居民。大多数（33%）发作发生在夏季（6 月至 8 月）（p=0.058）。与其他季节相比，夏季菌血症性蜂窝织炎的发生率明显更高（p=0.008）。蜂窝织炎是 SDSE 菌血症最常见的临床表现（所有发作的 68%）。复发性菌血症的危险因素包括慢性湿疹和/或皮肤糜烂（OR 3.96[95%CI 1.11-14.1]）、心脏病（OR 3.56[95%CI 1.22-10.4]）、糖尿病（OR 3.77[95%CI 1.35-10.5]）和蜂窝织炎病史。我们发现皮尔卡区 SDSE 菌血症的发病率非常高。以菌血症性蜂窝织炎为主的临床表现在夏季更为常见。复发性 SDSE 菌血症的危险因素是蜂窝织炎、慢性湿疹或皮肤糜烂、糖尿病和心脏病病史。
