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[理查德·西蒙(1859 - 1918):探险、记忆痕迹与表观遗传学]

[Richard Semon (1859-1918): expeditions, engrams and epigenetics].

作者信息

Förstl Hans

机构信息

Institut für Geschichte und Ethik der Medizin, TUM, Ismaningerstr. 22, 81675, München, Deutschland.

出版信息

Neuropsychiatr. 2023 Sep;37(3):147-155. doi: 10.1007/s40211-022-00454-9. Epub 2023 Jan 24.

Abstract

Richard Semon (1859-1918) was a student of Ernst Haeckel and began his career as a zoologist with work on sea urchins, starfish, chicken and lung fish, which he collected at the Mediterranean Sea and in Australia. After his return to Germany he was forced to leave Jena and the university due to private reasons, and settled in Munich, where Semon devoted most of his time to the more philosophical aspects of biology, developed the theory of "mneme" (1904), which he extended towards the inheritance of acquired characteristics (1912). Semon's concept of memory reached far beyond the brain and the individual person. In 1918 he took his life, despondent because of a surmised lack of scientific appreciation, the death of his beloved wife, the political turmoil at the end of WWI, and his-the memory researcher's-suspected loss of memory. Eight years later, the experimental biologist Paul Kammerer (1880-1926) from Vienna, Semon's must trusted source for the inheritance of acquired characteristics, also shot himself. Serious doubts increasingly overshadowed his work on salamanders and midwife toads. Epigenetics, the nature of memory, the fear of cognitive impairment, depression, the impact of private and political matters on scientific work, suspected scientific errors, fraud and a scientists' suicides are condensed in Semon's life and death.

摘要

理查德·西蒙(1859 - 1918)是恩斯特·海克尔的学生,他最初以动物学家的身份开启职业生涯,研究对象包括海胆、海星、鸡和肺鱼,这些样本是他在地中海和澳大利亚采集的。回到德国后,由于私人原因,他被迫离开耶拿和大学,定居慕尼黑,在那里西蒙将大部分时间投入到生物学更具哲学性的方面,发展了“记忆素”理论(1904年),并在1912年将其扩展到获得性特征的遗传方面。西蒙的记忆概念远远超越了大脑和个体本身。1918年,他自杀身亡,原因是推测缺乏科学认可、挚爱妻子的离世、第一次世界大战末期的政治动荡以及身为记忆研究者的他疑似失忆。八年后,来自维也纳的实验生物学家保罗·卡默勒(1880 - 1926)——西蒙在获得性特征遗传方面最信任的消息源——也开枪自杀了。他在蝾螈和产婆蟾方面的研究工作越来越多地被严重质疑所笼罩。表观遗传学、记忆的本质、对认知障碍的恐惧、抑郁、私人和政治事务对科学工作的影响、疑似科学错误、欺诈以及科学家的自杀,都浓缩在西蒙的生死之中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472b/10491508/2dda8bae9753/40211_2022_454_Fig1_HTML.jpg

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