Matsuda S, Suzuki M
Department of Obstetrics and Gynecology, Juntendo University School of Medicine.
Jpn J Antibiot. 1987 May;40(5):1041-6.
To evaluate the usefulness and the safety of cefuzonam (CZON, L-105) against obstetric and gynecological infections, we conducted clinical trials and obtained the results summarized as follows. 1. Thirteen patients with obstetric and gynecological infections (intrauterine infection 2 cases, adnexitis 7, 1 case each of abscess of adnexa uteri, abscess of the vaginal wall, pyelonephritis, and mammitis) were treated with CZON. The CZON was administered by intravenous injection or intravenous drip infusion, 1 g twice daily for 4 to 7 days (8 g to 14 g in total). The clinical effect was good in 12 and poor in 1. 2. Four cases, on which other antimicrobial agents were ineffective, responded well to CZON. 3. The CZON displayed excellent effects on anaerobic bacteria (Peptostreptococcus anaerobius, Bacteroides fragilis) and Gram negative rods (Escherichia coli, Klebsiella pneumoniae). 4. No side effects or laboratory abnormalities were observed. 5. From the above results, CZON appeared to be an effective and useful drug for obstetric and gynecological infections.
为评估头孢唑南（CZON，L - 105）治疗妇产科感染的有效性和安全性，我们进行了临床试验，结果总结如下。1. 13例妇产科感染患者（宫内感染2例，附件炎7例，子宫附件脓肿、阴道壁脓肿、肾盂肾炎和乳腺炎各1例）接受了头孢唑南治疗。头孢唑南通过静脉注射或静脉滴注给药，每日2次，每次1 g，共4至7天（总计8 g至14 g）。临床疗效良好者12例，不佳者1例。2. 4例使用其他抗菌药物无效的患者对头孢唑南反应良好。3. 头孢唑南对厌氧菌（厌氧消化链球菌、脆弱拟杆菌）和革兰氏阴性杆菌（大肠杆菌、肺炎克雷伯菌）显示出优异疗效。4. 未观察到副作用或实验室检查异常。5. 根据上述结果，头孢唑南似乎是治疗妇产科感染的一种有效且有用的药物。
