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肿瘤浸润淋巴细胞和巨噬细胞作为胆道癌的一个显著预后因素。

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer.

机构信息

Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

出版信息

PLoS One. 2023 Jan 24;18(1):e0280348. doi: 10.1371/journal.pone.0280348. eCollection 2023.

DOI:10.1371/journal.pone.0280348
PMID:36693070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9873170/
Abstract

BACKGROUND

The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment (TME).

METHODS

A total of 130 patients with BTC who underwent surgical treatment at our institution were enrolled in this study. We retrospectively evaluated TILs and TAMs with immunohistochemical staining.

RESULTS

With CD8-high, CD4-high, FOXP3-high, and CD68-low in TME as one factor, we calculated Immunoscore according to the number of factors. The high Immunoscore group showed significantly superior overall survival (OS) and recurrence-free survival (RFS) than the low Immunoscore group (median OS, 60.8 vs. 26.4 months, p = 0.001; median RFS not reached vs. 17.2 months, p < 0.001). Also, high Immunoscore was an independent good prognostic factor for OS and RFS (hazards ratio 2.05 and 2.41 and p = 0.01 and p = 0.001, respectively).

CONCLUSIONS

High Immunoscore group had significantly superior OS and RFS and was an independent good prognostic factor for OS and RFS.

摘要

背景

肿瘤浸润淋巴细胞（TILs）和肿瘤相关巨噬细胞（TAMs）对胆道癌（BTC）预后的影响尚不完全清楚。因此，在本研究中，我们研究了肿瘤微环境（TME）中各种免疫细胞浸润的影响。

方法

本研究共纳入在我院接受手术治疗的 130 例 BTC 患者。我们采用免疫组织化学染色法对 TILs 和 TAMs 进行了回顾性评估。

结果

以 TME 中 CD8-high、CD4-high、FOXP3-high 和 CD68-low 为一个因素，根据因素数量计算免疫评分。高免疫评分组的总生存（OS）和无复发生存（RFS）明显优于低免疫评分组（中位 OS：60.8 与 26.4 个月，p = 0.001；中位 RFS 未达到与 17.2 个月，p < 0.001）。此外，高免疫评分是 OS 和 RFS 的独立预后良好因素（风险比 2.05 和 2.41，p = 0.01 和 p = 0.001）。

结论

高免疫评分组的 OS 和 RFS 明显更好，是 OS 和 RFS 的独立预后良好因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/55112af66ce2/pone.0280348.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/d4d8c92b91e1/pone.0280348.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/3fa1c9a11872/pone.0280348.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/86f76cd4e87e/pone.0280348.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/55112af66ce2/pone.0280348.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/d4d8c92b91e1/pone.0280348.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/3fa1c9a11872/pone.0280348.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/86f76cd4e87e/pone.0280348.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c8/9873170/55112af66ce2/pone.0280348.g004.jpg

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1
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2
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Front Immunol. 2021 Jul 20;12:715234. doi: 10.3389/fimmu.2021.715234. eCollection 2021.
3
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.癌症免疫疗法的历史与进展：了解肿瘤浸润免疫细胞的特征及其治疗意义。
PD-1 抑制剂联合治疗在晚期胆道癌一线治疗中的生存获益和生物标志物：一项回顾性研究。
Cancer Med. 2023 Nov;12(22):20699-20711. doi: 10.1002/cam4.6628. Epub 2023 Nov 6.
Cell Mol Immunol. 2020 Aug;17(8):807-821. doi: 10.1038/s41423-020-0488-6. Epub 2020 Jul 1.
4
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Anticancer Res. 2020 May;40(5):2881-2887. doi: 10.21873/anticanres.14264.
5
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JHEP Rep. 2019 Jul 10;1(4):297-311. doi: 10.1016/j.jhepr.2019.06.003. eCollection 2019 Oct.
6
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7
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