Teimouri Aref, Goudarzi Fatemeh, Goudarzi Kimia, Alimi Rasoul, Sahebi Keivan, Foroozand Hassan, Keshavarz Hossein
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Parasitol. 2022 Oct-Dec;17(4):443-457. doi: 10.18502/ijpa.v17i4.11271.
infection (toxoplasmosis) has the potential to cause a serious disease in immunocompromised patients and can be fatal in this population. We conducted a systematic review and meta-analysis to assess comprehensively the pooled seroprevalence of toxoplasmosis among immunocompromised patients including HIV/AIDS patients, cancer patients, and transplant recipients in Iran.
PubMed, Web of Science, Scopus, Embase, and Google Scholar databases (international) and Scientific Information Database (SID), Magiran, IranMedex, and IranDoc databases (national) were systematically searched for all reports that possibly contained data for prevalence in different immunocompromised populations in Iran between 2013 and 2022.
Overall, IgG seroprevalence rate of toxoplasmosis in Iranian immunocompromised patients was 45.1% (95% confidence interval (CI), 37.4-52.9). IgG seroprevalence rate of toxoplasmosis in 12 studies that included 2279 cancer patients, 19 studies that included 2565 HIV/AIDS patients and in 3 studies that included 200 transplant recipients was 43.6% (95% CI, 30.2-57.0), 45.9% (95% CI, 34.8-57.1) and 45.8% (95% CI, 32.5-59.0), respectively. Moreover, IgM seroprevalence rate in the 26 studies was 2.6% (95% CI, 1.4-3.7).
Our findings represent a high seroprevalence rate of IgG among immunocompromised patients. Health improvement and education toward prevention of toxoplasmosis is of great importance for these susceptible populations.
感染（弓形虫病）有可能在免疫功能低下的患者中引发严重疾病，并且在这一人群中可能是致命的。我们进行了一项系统综述和荟萃分析，以全面评估伊朗免疫功能低下患者（包括艾滋病毒/艾滋病患者、癌症患者和移植受者）中弓形虫病的合并血清阳性率。
对PubMed、科学网、Scopus、Embase和谷歌学术数据库（国际）以及科学信息数据库（SID）、Magiran、IranMedex和IranDoc数据库（国内）进行系统检索，以查找2013年至2022年期间可能包含伊朗不同免疫功能低下人群患病率数据的所有报告。
总体而言，伊朗免疫功能低下患者中弓形虫病的IgG血清阳性率为45.1%（95%置信区间（CI），37.4 - 52.9）。在纳入2279名癌症患者的12项研究、纳入2565名艾滋病毒/艾滋病患者的19项研究以及纳入200名移植受者的3项研究中，弓形虫病的IgG血清阳性率分别为43.6%（95% CI，30.2 - 57.0）、45.9%（95% CI，34.8 - 57.1）和45.8%（95% CI，32.5 - 59.0）。此外，26项研究中的IgM血清阳性率为2.6%（95% CI，1.4 - 3.7）。
我们的研究结果表明免疫功能低下患者中IgG血清阳性率很高。对这些易感人群进行改善健康和预防弓形虫病的教育非常重要。
