Dhanalakshmi M, Sruthi D, Jinuraj K R, Das Kajari, Dave Sushma, Andal N Muthulakshmi, Das Jayashankar
Research and Development Centre, Bharathiar University, Coimbatore, 641046 Tamil Nadu India.
Department of Biochemistry, Indian Institute of Science, Bengaluru, 560012 India.
Med Chem Res. 2023;32(3):391-408. doi: 10.1007/s00044-023-03015-z. Epub 2023 Jan 20.
There are a plethora of antibiotic resistance cases and humans are marching towards another big survival test of evolution along with drastic climate change and infectious diseases. Ever since the first antibiotic [penicillin], and the myriad of vaccines, we were privileged to escape many infectious disease threats. The survival technique of pathogens seems rapidly changing and sometimes mimicking our own systems in such a perfect manner that we are left unarmed against them. Apart from searching for natural alternatives, repurposing existing drugs more effectively is becoming a familiar approach to new therapeutic opportunities. The ingenious use of revolutionary artificial intelligence-enabled drug discovery techniques is coping with the speed of such alterations. D-Mannose is a great hope as a nutraceutical in drug discovery, against CDG, diabetes, obesity, lung disease, and autoimmune diseases and recent findings of anti-tumor activity make it interesting along with its role in drug delivery enhancing techniques. A very unique work done in the present investigation is the collection of data from the ChEMBL database and presenting the targetable proteins on pathogens as well as on humans. It shows Mannose has 50 targets and the majority of them are on human beings. The structure and conformation of certain monosaccharides have a decisive role in receptor pathogen interactions and here we attempt to review the multifaceted roles of Mannose sugar, its targets associated with different diseases, as a natural molecule having many success stories as a drug and future hope for disease management.
存在大量抗生素耐药性病例，而且随着剧烈的气候变化和传染病的出现，人类正迈向进化的又一次重大生存考验。自从第一种抗生素（青霉素）以及无数疫苗问世以来，我们有幸躲过了许多传染病的威胁。病原体的生存技巧似乎在迅速变化，有时以一种完美的方式模仿我们自身的系统，以至于我们对它们毫无防备。除了寻找天然替代品外，更有效地重新利用现有药物正成为探索新治疗机会的一种常见方法。巧妙运用具有革命性的人工智能辅助药物发现技术正在应对这种变化的速度。D - 甘露糖作为药物发现中的一种营养保健品，有望用于治疗先天性糖基化障碍（CDG）、糖尿病、肥胖症、肺部疾病和自身免疫性疾病，而且其抗肿瘤活性的最新发现以及在药物递送增强技术中的作用使其备受关注。本研究中一项非常独特的工作是从ChEMBL数据库收集数据，并展示病原体以及人类身上的可靶向蛋白质。结果显示甘露糖有50个靶点，其中大多数在人类身上。某些单糖的结构和构象在受体与病原体的相互作用中起决定性作用，在此我们试图综述甘露糖的多方面作用、其与不同疾病相关的靶点，甘露糖作为一种天然分子，在药物领域有诸多成功案例，也是疾病管理的未来希望。
