Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
Anal Chim Acta. 2023 Feb 22;1243:340781. doi: 10.1016/j.aca.2023.340781. Epub 2023 Jan 6.
The construction of uniformly dispersed structure with abundant active sites is crucial for fast electron transport and advancing electrocatalytic reactions. Herein, FeCoO-rGO was prepared by depositing Fe and Co bimetallic oxides in-situ on reduced graphene oxide through a simple process combined hydrothermal reaction and calcination. Fe was elaborately introduced into the synthesis of metal oxides to alleviate the aggregation of cobalt oxides and obtain nanocomposites with homogeneously structured and abundant redox sites, and the bimetallic oxides nanomaterials had enhanced electrocatalysis under the synergistic effect. The flexible electrode prepared from FeCoO-rGO exhibited excellent detection performance for glucose with a detection limit down low to 0.07 μM and a sensitivity of 1510 μM cm mA. The adoption of flexible substrates improved the wearability of the electrode and broadened its practicality for detecting biomarkers on the skin surface. The constructed sensor was successfully used in the dynamic analysis of glucose content in tears, and the results were highly consistent with the test outcome of a commercial test kit, demonstrating its application prospects in non-invasive epidermal diabetes mellitus diagnosis.
构建具有丰富活性位点的均匀分散结构对于促进快速电子传递和电催化反应至关重要。在此，通过将水热反应和煅烧相结合的简单工艺，将 Fe 和 Co 双金属氧化物原位沉积在还原氧化石墨烯上，制备了 FeCoO-rGO。Fe 的精心引入缓解了钴氧化物的聚集，得到了具有均匀结构和丰富氧化还原位点的纳米复合材料，并且双金属氧化物纳米材料在协同作用下增强了电催化性能。由 FeCoO-rGO 制备的柔性电极对葡萄糖表现出优异的检测性能，检测限低至 0.07 μM，灵敏度为 1510 μM cm mA。采用柔性基底提高了电极的可穿戴性，拓宽了其在检测皮肤表面生物标志物方面的实用性。构建的传感器成功地用于泪液中葡萄糖含量的动态分析，与商业试剂盒的测试结果高度一致，表明其在非侵入性表皮糖尿病诊断中的应用前景。
