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代谢物医学提供了一条超越代谢物列表的途径。

Metabolite medicine offers a path beyond lists of metabolites.

作者信息

Shaham-Niv Shira, Rencus-Lazar Sigal, Gazit Ehud

机构信息

BLAVATNIK CENTER for Drug Discovery, Tel Aviv University, Tel Aviv, Israel.

The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

出版信息

Commun Chem. 2021 Aug 5;4(1):115. doi: 10.1038/s42004-021-00551-w.

DOI:10.1038/s42004-021-00551-w
PMID:36697841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9814037/
Abstract

Aimed to decipher the levels of metabolites, metabolomics can now advance to unraveling their functionalities in various contexts. Here, the authors present the metabolite medicine concept, integrating classical metabolomics methods with advanced computational and structural tools to facilitate functional studies.

摘要

旨在破译代谢物水平的代谢组学,如今已发展到在各种背景下揭示其功能。在此,作者提出了代谢物医学概念,将经典代谢组学方法与先进的计算和结构工具相结合,以促进功能研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/9814037/a7d5ace3ba82/42004_2021_551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/9814037/01946613bbfa/42004_2021_551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/9814037/a7d5ace3ba82/42004_2021_551_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/9814037/01946613bbfa/42004_2021_551_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7255/9814037/a7d5ace3ba82/42004_2021_551_Fig2_HTML.jpg

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Polishing the crystal ball: mining multi-omics data in dermatomyositis.擦亮水晶球:挖掘皮肌炎中的多组学数据。
Ann Transl Med. 2021 Mar;9(5):435. doi: 10.21037/atm-20-5319.
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Novel approaches to liver disease diagnosis and modeling.肝病诊断与建模的新方法。
Transl Gastroenterol Hepatol. 2021 Apr 5;6:19. doi: 10.21037/tgh-20-109. eCollection 2021.
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Integrative Omics to Characterize and Classify Pulmonary Vascular Disease.综合组学分析用于描述和分类肺血管疾病。
Clin Chest Med. 2021 Mar;42(1):195-205. doi: 10.1016/j.ccm.2020.10.001. Epub 2021 Jan 12.
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FUNCTIONAL METABOLOMICS DECIPHER BIOCHEMICAL FUNCTIONS AND ASSOCIATED MECHANISMS UNDERLIE SMALL-MOLECULE METABOLISM.功能代谢组学揭示了小分子代谢下的生化功能和相关机制。
Mass Spectrom Rev. 2020 Sep;39(5-6):417-433. doi: 10.1002/mas.21611. Epub 2019 Nov 4.
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Phenylketonuria, co-morbidity, and ageing: A review.苯丙酮尿症、共病和衰老:综述。
J Inherit Metab Dis. 2020 Mar;43(2):167-178. doi: 10.1002/jimd.12186. Epub 2020 Jan 1.
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Dialogues Clin Neurosci. 2018 Dec;20(4):301-325. doi: 10.31887/DCNS.2018.20.4/jmsaudubray.
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Functional Modules of the Proteostasis Network.蛋白质稳态网络的功能模块。
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