• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微观流变学：从视频显微镜到光镊

Microrheology: From Video Microscopy to Optical Tweezers.

作者信息

Fernandez Andrea Jannina, Gibson Graham M, Rył Anna, Tassieri Manlio

机构信息

Division of Biomedical Engineering, James Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, UK.

School of Physics and Astronomy, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, UK.

出版信息

Micromachines (Basel). 2025 Aug 8;16(8):918. doi: 10.3390/mi16080918.

DOI:10.3390/mi16080918
PMID:40872425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12388072/
Abstract

Microrheology, a branch of rheology, focuses on studying the flow and deformation of matter at micron length scales, enabling the characterization of materials using minute sample volumes. This review article explores the principles and advancements of microrheology, covering a range of techniques that infer the viscoelastic properties of soft materials from the motion of embedded tracer particles. Special emphasis is placed on methods employing optical tweezers, which have emerged as a powerful tool in both passive and active microrheology thanks to their exceptional force sensitivity and spatiotemporal resolution. The review also highlights complementary techniques such as video particle tracking, magnetic tweezers, dynamic light scattering, and atomic force microscopy. Applications across biology, materials science, and soft matter research are discussed, emphasizing the growing relevance of particle tracking microrheology and optical tweezers in probing microscale mechanics.

摘要

微观流变学是流变学的一个分支，专注于研究微米长度尺度下物质的流动和变形，能够使用微量样品对材料进行表征。这篇综述文章探讨了微观流变学的原理和进展，涵盖了一系列从嵌入示踪粒子的运动推断软材料粘弹性特性的技术。特别强调了采用光镊的方法，由于其出色的力灵敏度和时空分辨率，光镊已成为被动和主动微观流变学中的强大工具。该综述还突出了视频粒子跟踪、磁镊、动态光散射和原子力显微镜等互补技术。讨论了在生物学、材料科学和软物质研究中的应用，强调了粒子跟踪微观流变学和光镊在探测微观尺度力学方面日益增长的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/83c663df84f6/micromachines-16-00918-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bcfa6a4a9f84/micromachines-16-00918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/b25f1c6f6779/micromachines-16-00918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/6d434b00a771/micromachines-16-00918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/e70644bb586c/micromachines-16-00918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/41dc88f0d7d9/micromachines-16-00918-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/5b5b9053e61f/micromachines-16-00918-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/4eda39cbb85b/micromachines-16-00918-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/85f398727dc0/micromachines-16-00918-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/5c2a897ae388/micromachines-16-00918-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/a73bcadc0cf2/micromachines-16-00918-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bb3279abd62d/micromachines-16-00918-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/f090cd6683dd/micromachines-16-00918-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/6922bc2661f4/micromachines-16-00918-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/7a2e3c0dbeee/micromachines-16-00918-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/89d0ea30da88/micromachines-16-00918-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/db226f214357/micromachines-16-00918-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/67d48845c458/micromachines-16-00918-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/c92d0f524820/micromachines-16-00918-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bfef1db6d473/micromachines-16-00918-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/c3cfc4687f40/micromachines-16-00918-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/20c7acc27bcc/micromachines-16-00918-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/83c663df84f6/micromachines-16-00918-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bcfa6a4a9f84/micromachines-16-00918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/b25f1c6f6779/micromachines-16-00918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/6d434b00a771/micromachines-16-00918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/e70644bb586c/micromachines-16-00918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/41dc88f0d7d9/micromachines-16-00918-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/5b5b9053e61f/micromachines-16-00918-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/4eda39cbb85b/micromachines-16-00918-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/85f398727dc0/micromachines-16-00918-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/5c2a897ae388/micromachines-16-00918-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/a73bcadc0cf2/micromachines-16-00918-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bb3279abd62d/micromachines-16-00918-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/f090cd6683dd/micromachines-16-00918-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/6922bc2661f4/micromachines-16-00918-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/7a2e3c0dbeee/micromachines-16-00918-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/89d0ea30da88/micromachines-16-00918-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/db226f214357/micromachines-16-00918-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/67d48845c458/micromachines-16-00918-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/c92d0f524820/micromachines-16-00918-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/bfef1db6d473/micromachines-16-00918-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/c3cfc4687f40/micromachines-16-00918-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/20c7acc27bcc/micromachines-16-00918-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3690/12388072/83c663df84f6/micromachines-16-00918-g022.jpg

相似文献

1
Microrheology: From Video Microscopy to Optical Tweezers.微观流变学：从视频显微镜到光镊
Micromachines (Basel). 2025 Aug 8;16(8):918. doi: 10.3390/mi16080918.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
3
PyFMLab: Open-source software for atomic force microscopy microrheology data analysis.PyFMLab：用于原子力显微镜微流变数据分析的开源软件。
Open Res Eur. 2024 Jul 24;3:187. doi: 10.12688/openreseurope.16550.1. eCollection 2023.
4
Information-Providing Magnetic Supraparticles: Particle Designs to Record Environmental Stimuli with Readout by Magnetic Particle Spectroscopy.信息提供磁性超粒子：通过磁性粒子光谱读出记录环境刺激的粒子设计
Acc Mater Res. 2025 May 23;6(7):842-852. doi: 10.1021/accountsmr.5c00027. eCollection 2025 Jul 25.
5
Electrophoresis电泳
6
The agreement of phonetic transcriptions between paediatric speech and language therapists transcribing a disordered speech sample.儿科言语和语言治疗师转写语音样本的音标转录的一致性。
Int J Lang Commun Disord. 2024 Sep-Oct;59(5):1981-1995. doi: 10.1111/1460-6984.13043. Epub 2024 Jun 8.
7
Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation.首次就诊时磁共振灌注成像用于鉴别低级别与高级别胶质瘤
Cochrane Database Syst Rev. 2018 Jan 22;1(1):CD011551. doi: 10.1002/14651858.CD011551.pub2.
8
Management of urinary stones by experts in stone disease (ESD 2025).结石病专家对尿路结石的管理（2025年结石病专家共识）
Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085.
9
Short-Term Memory Impairment短期记忆障碍
10
Anterior Approach Total Ankle Arthroplasty with Patient-Specific Cut Guides.使用患者特异性截骨导向器的前路全踝关节置换术。
JBJS Essent Surg Tech. 2025 Aug 15;15(3). doi: 10.2106/JBJS.ST.23.00027. eCollection 2025 Jul-Sep.

本文引用的文献

1
The mitotic chromosome periphery modulates chromosome mechanics.有丝分裂染色体周边区域调节染色体力学。
Nat Commun. 2025 Jul 10;16(1):6399. doi: 10.1038/s41467-025-61755-5.
2
Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.尺度相关相互作用使肌动蛋白-中间丝复合材料表现出突发的微观流变学应力响应。
Soft Matter. 2024 Nov 20;20(45):9007-9021. doi: 10.1039/d4sm00988f.
3
Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates.序列特异性相互作用决定了蛋白质凝聚物的粘弹性和老化动力学。
Nat Phys. 2024 Sep;20(9):1482-1491. doi: 10.1038/s41567-024-02558-1. Epub 2024 Jul 2.
4
Dynamic Light Scattering Microrheology of Phase-Separated Poly(vinyl) Alcohol-Phytagel Blends.相分离聚乙烯醇-植物凝胶共混物的动态光散射微流变学
Polymers (Basel). 2024 Oct 11;16(20):2875. doi: 10.3390/polym16202875.
5
Optical Halo: A Proof of Concept for a New Broadband Microrheology Tool.光学晕圈：一种新型宽带微观流变学工具的概念验证
Micromachines (Basel). 2024 Jul 7;15(7):889. doi: 10.3390/mi15070889.
6
The viscoelasticity of high concentration monoclonal antibodies using particle tracking microrheology.使用粒子追踪微流变学研究高浓度单克隆抗体的粘弹性
APL Bioeng. 2024 Apr 24;8(2):026105. doi: 10.1063/5.0201626. eCollection 2024 Jun.
7
Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.注意粘性模量：各向同性弹性基质粘性性质的机械转导反应调节干细胞软骨形成。
Adv Healthc Mater. 2024 Apr;13(9):e2302571. doi: 10.1002/adhm.202302571. Epub 2023 Dec 12.
8
Atomic force microscopy-mediated mechanobiological profiling of complex human tissues.原子力显微镜介导的复杂人体组织的机械生物学分析。
Biomaterials. 2023 Dec;303:122389. doi: 10.1016/j.biomaterials.2023.122389. Epub 2023 Nov 11.
9
Living cells as a biological analog of optical tweezers - a non-invasive microrheology approach.活细胞作为光镊的生物模拟——一种非侵入性的微流变学方法。
Acta Biomater. 2023 Aug;166:317-325. doi: 10.1016/j.actbio.2023.04.039. Epub 2023 May 1.
10
OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.OptoRheo：实时 3D 生物系统的原位微机械传感与成像。
Commun Biol. 2023 Apr 28;6(1):463. doi: 10.1038/s42003-023-04780-8.