Maurya Shashank Kumar, Gupta Suchi, Mishra Rajnikant
Biochemistry and Molecular Biology Laboratory, Department of Zoology, University of Delhi, New Delhi, India.
Tech Cell Innovations Private Limited, Centre for Medical Innovation and Entrepreneurship (CMIE), All India Institute of Medical Sciences, New Delhi, India.
Front Mol Neurosci. 2023 Jan 9;15:1072046. doi: 10.3389/fnmol.2022.1072046. eCollection 2022.
The emerging role of microglia in brain homeostasis, neurodegeneration, and neurodevelopmental disorders has attracted considerable interest. In addition, recent developments in microglial functions and associated pathways have shed new light on their fundamental role in the immunological surveillance of the brain. Understanding the interconnections between microglia, neurons, and non-neuronal cells have opened up additional avenues for research in this evolving field. Furthermore, the study of microglia at the transcriptional and epigenetic levels has enhanced our knowledge of these native brain immune cells. Moreover, exploring various facets of microglia biology will facilitate the early detection, treatment, and management of neurological disorders. Consequently, the present review aimed to provide comprehensive insight on microglia biology and its influence on brain development, homeostasis, management of disease, and highlights microglia as potential therapeutic targets in neurodegenerative and neurodevelopmental diseases.
小胶质细胞在脑内稳态、神经退行性变和神经发育障碍中日益凸显的作用已引起了广泛关注。此外，小胶质细胞功能及相关信号通路的最新进展为其在脑免疫监视中的基础作用提供了新的见解。了解小胶质细胞、神经元和非神经元细胞之间的相互联系为这个不断发展的领域开辟了更多的研究途径。此外，在转录和表观遗传水平上对小胶质细胞的研究增进了我们对这些脑内固有免疫细胞的认识。而且，探索小胶质细胞生物学的各个方面将有助于神经系统疾病的早期检测、治疗和管理。因此，本综述旨在全面深入地探讨小胶质细胞生物学及其对脑发育、稳态、疾病管理的影响，并强调小胶质细胞作为神经退行性疾病和神经发育疾病潜在治疗靶点的重要性。
