Nguyen Tin Hoang, Nguyen Kien Trung, Tran Long Duc, Le An Thi Thuy, Phung Thu Minh, Banh Truc Thi Ngoc, Vo Trang Thi, Bodo Michael
Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Department of Functional Diagnostics, Can Tho University of Medicine and Pharmacy Hospital, Can Tho, Vietnam.
J Electr Bioimpedance. 2022 Dec 18;13(1):78-87. doi: 10.2478/joeb-2022-0012. eCollection 2022 Jan.
The significant drop in estrogen levels during menopause increases the cardiovascular risks, one of which is cerebrovascular atherosclerosis. Research on rheoencephalography (REG) parameters for the early diagnosis of cerebrovascular atherosclerotic lesions is of great interest to scientists because of its ease of implementation, low cost, and non-invasiveness. The objectives of study are to evaluate the vascular tone, cerebral circulation flow in each hemisphere of the brain of menopausal women, and some associated factors through waveform characteristics and parameters in REG. A controlled cross-sectional descriptive study was conducted on a group of patients including 80 menopausal women and a control group of 46 menstruating women. All patients were measured REG in the frontal-occipital leads by VasoScreen 5000 impedance REG meter. In menopausal women, the percentage of sharp waves, the percentage of clear side waves, and the average REG were all lower than in the control group (p<0.01). The mean conduction time and mean slope ratio was lower than the control group (p<0.001). The mean peak time was higher than the control group (p<0.01). The mean elasticity index (alpha/T) was higher than the control group (p<0.001). Menopausal women have increased vascular tone, the highest in the group of women 50-60 years old, menopause <5 years, having a habit of eating red meat; and decreased blood flow intensity, the highest in the group of women <50 years old. However, the difference was statistically significant only in the left hemisphere (p<0.05). Vascular hypertonia in menopausal women with central obesity was higher than in the non-obese group in both hemispheres (p<0.05). In conclusion, menopausal women had atherosclerosis in both hemispheres of the brain, which was clearly shown in the rate of increased vascular tone. Central obesity may increase the risk of vascular hypertonia 3.75 times in the right and 5.44 times in the left hemisphere.
更年期雌激素水平的显著下降会增加心血管疾病风险，其中之一就是脑血管动脉粥样硬化。由于脑电阻抗图（REG）检查易于实施、成本低廉且无创，因此利用REG参数早期诊断脑血管动脉粥样硬化病变的研究备受科学家关注。本研究的目的是通过REG的波形特征和参数，评估更年期女性大脑各半球的血管张力、脑循环血流量以及一些相关因素。对一组包括80名更年期女性的患者和46名处于经期的女性组成的对照组进行了一项对照横断面描述性研究。所有患者均使用VasoScreen 5000阻抗REG仪在额枕导联测量REG。更年期女性的尖波百分比、清晰侧波百分比和平均REG均低于对照组（p<0.01）。平均传导时间和平均斜率比低于对照组（p<0.001）。平均峰值时间高于对照组（p<0.01）。平均弹性指数（α/T）高于对照组（p<0.001）。更年期女性的血管张力增加，在50 - 60岁、绝经<5年且有食用红肉习惯的女性组中最高；血流强度降低，在<50岁的女性组中最高。然而，差异仅在左半球具有统计学意义（p<0.05）。中心性肥胖的更年期女性在两个半球的血管张力亢进均高于非肥胖组（p<0.05）。总之，更年期女性大脑的两个半球均存在动脉粥样硬化，这在血管张力增加率上表现明显。中心性肥胖可能使右半球血管张力亢进风险增加3.75倍，左半球增加5.44倍。
