Li Zhengrui, Fu Rao, Wen Xutao, Wang Qi, Huang Xufeng, Zhang Ling
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Front Physiol. 2023 Jan 9;13:1089539. doi: 10.3389/fphys.2022.1089539. eCollection 2022.
The microbiota is a critical component of the complex human microenvironment, impacting various physiological processes and disease development the microbe-host interaction. In particular, the oral microbiota profoundly affects tumor development and progression. There is increasing evidence that oral microbiota is associated with the development of oral cancer, especially oral squamous cell carcinoma (OSCC). We comprehensively analyzed the oral microbiota in 133 OSCC samples worldwide. Subsequently, we evaluated the microbial compositions between OSCC patients and healthy people and their correlation with clinical parameters. The value of the oral microbiota as a diagnostic and prognostic biomarker was also determined. This study found differences in critical oral microbiota between OSCC and normal controls. The most notable differences are present in , , , , , and . All six-level oral microorganisms were also associated with the clinical characteristics of OSCC, particularly with the clinical outcomes (survival time and status). We developed a predictive model based on this. We found that five different oral microorganisms have high confidence and can be used for clinical diagnosis and prognostic prediction, except for . This study revealed that the intratumor oral microbiota of OSCC patients worldwide and the microbial signatures of OSCC patients possess similar properties in different regions, further refining the shortcomings of the current research field. We revealed that the oral microbiota could be used as a biomarker to reflect human health and disease progression status. This will provide new directions for tumor microbiome research. This means we can develop strategies through diet, probiotics, and antibiotics for cancer prevention and treatment.
微生物群是复杂人类微环境的关键组成部分，影响着各种生理过程和疾病发展，即微生物与宿主的相互作用。特别是，口腔微生物群深刻影响肿瘤的发展和进程。越来越多的证据表明，口腔微生物群与口腔癌尤其是口腔鳞状细胞癌（OSCC）的发生有关。我们全面分析了全球133份OSCC样本中的口腔微生物群。随后，我们评估了OSCC患者与健康人之间的微生物组成及其与临床参数的相关性。还确定了口腔微生物群作为诊断和预后生物标志物的价值。本研究发现OSCC与正常对照之间关键口腔微生物群存在差异。最显著的差异存在于……、……、……、……、……和……中。所有六个层面的口腔微生物也与OSCC的临床特征相关，特别是与临床结果（生存时间和状态）相关。基于此我们开发了一个预测模型。我们发现除了……之外，五种不同的口腔微生物具有很高的可信度，可用于临床诊断和预后预测。这项研究表明，全球范围内OSCC患者的肿瘤内口腔微生物群以及OSCC患者的微生物特征在不同地区具有相似的特性，进一步完善了当前研究领域的不足。我们揭示了口腔微生物群可作为反映人类健康和疾病进展状态的生物标志物。这将为肿瘤微生物组研究提供新的方向。这意味着我们可以通过饮食、益生菌和抗生素制定策略来预防和治疗癌症。
