Research Group of Medical Microbiology, Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Semin Cancer Biol. 2022 Nov;86(Pt 3):633-642. doi: 10.1016/j.semcancer.2021.11.002. Epub 2021 Nov 4.
Despite decades of research, cancer continues to be a major global health concern. In recent years, the role played by microorganisms in the development and progression of cancer has come under increased scrutiny. The aim of the present review is to highlight the main associations between members of the human oral microbiota and various cancers. The PubMed database was searched for available literature to outline the current state of understanding regarding the role of the oral microbiota and a variety of human cancers. Oral squamous cell carcinoma (OSCC) is associated with carriage of a number of oral bacteria (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus sp.), certain viruses (e.g., human papilloma virus, human herpes virus 8, herpes simplex virus 1 and Epstein-Barr virus) and yeast (Candida albicans). Moreover, members of the oral microbiota are associated with cancers of the esophagus, stomach, pancreas, colon/rectum and lung. Furthermore, the present review outlines a number of the carcinogenic mechanisms underlying the presented microbial associations with cancer. Such information may one day help clinicians to diagnose neoplastic diseases at earlier stages and prescribe treatments that take into account the possible microbial nature of carcinogenesis.
尽管已经进行了几十年的研究，但癌症仍然是一个全球性的主要健康问题。近年来，微生物在癌症的发生和发展中所起的作用受到了越来越多的关注。本综述的目的是强调人类口腔微生物群与各种癌症之间的主要关联。本文检索了 PubMed 数据库中有关口腔微生物群和各种人类癌症作用的现有文献，概述了目前对这一问题的理解。口腔鳞状细胞癌（OSCC）与多种口腔细菌（如牙龈卟啉单胞菌、具核梭杆菌、链球菌属）、某些病毒（如人乳头瘤病毒、人类疱疹病毒 8、单纯疱疹病毒 1 和爱泼斯坦-巴尔病毒）和酵母（白色念珠菌）的携带有关。此外，口腔微生物群成员与食管、胃、胰腺、结肠/直肠和肺癌有关。此外，本综述还概述了目前提出的微生物与癌症关联的一些致癌机制。这些信息将来可能有助于临床医生在更早的阶段诊断肿瘤性疾病，并开出考虑到致癌发生可能的微生物性质的治疗方案。
