Tropical Nephrology Research Unit, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Tropical Immunology and Translational Research Unit, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Cells. 2022 Feb 16;11(4):698. doi: 10.3390/cells11040698.
Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious disease caused by spp., as well as a reemerging disease and global public health problem with respect to morbidity and mortality both in humans and animals. Leptospirosis emerges as a leading cause of acute febrile illness along with hepatorenal injury in many countries, including Thailand. While most affected persons are symptomatic in acute disease, which is always difficult to differentiate from other tropical diseases, there is growing evidence of subtle manifestations that cause unrecognized chronic symptoms. The kidney is one of the common organs affected by Leptospires. Although acute kidney injury in the spectrum of interstitial nephritis is a well-described characteristic in severe leptospirosis, chronic kidney disease from leptospirosis is widely discussed. Early recognition of severe leptospirosis leads to reduce morbidity and mortality. Thus, in this review, we highlight the spectrum of characteristics involved in leptospirosis kidney disease and the use of serologic and molecular methods, as well as the treatments of severe leptospirosis.
钩端螺旋体病是一种全球性的人畜共患和水源性疾病。它是一种由 spp.引起的被忽视的传染病，也是一种重新出现的疾病，涉及人类和动物的发病率和死亡率，是一个全球性的公共卫生问题。在包括泰国在内的许多国家，钩端螺旋体病已成为导致急性发热疾病和肝肾功能损害的主要原因。虽然大多数受感染者在急性疾病中出现症状，这总是难以与其他热带疾病区分，但越来越多的证据表明存在引起未被识别的慢性症状的微妙表现。肾脏是受钩端螺旋体影响的常见器官之一。虽然在严重钩端螺旋体病中，间质性肾炎谱中的急性肾损伤是一个特征明显的特征，但钩端螺旋体病引起的慢性肾脏病却广泛讨论。早期识别严重钩端螺旋体病可降低发病率和死亡率。因此，在这篇综述中，我们强调了钩端螺旋体肾病的特征谱以及血清学和分子方法的应用，以及严重钩端螺旋体病的治疗。
