Department of Food Science and Engineering, Ningbo University, Ningbo 315211, P.R. China.
Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, United States.
J Agric Food Chem. 2023 Feb 15;71(6):2718-2733. doi: 10.1021/acs.jafc.2c07742. Epub 2023 Jan 26.
Gut-brain connections may be mediated by an assortment of microbial molecules, which can subsequently traverse intestinal and blood-brain barriers and impact neurological function. Pattern recognition receptors (PRRs) are important innate immune proteins in the gut. Gut microbiota act in concert with the PRRs is a novel target for regulating host-microbe signaling and immune homeostasis, which may involve the pathogenesis of neurodegenerative diseases. Natural food bioactives bestow a protective advantage on neurodegenerative diseases through immunomodulatory effects of the modified gut microbiota or alterations in the landscape of microbiota-produced metabolites via PRRs modulation. In this review, we discuss the effect of natural food bioactives on the gut microbiota and the role of PRRs in the gut-brain crosstalk. We focused on the neuroprotective mechanisms of natural bioactive compounds behind the action of the gut microbiota and PRRs. Research advances in natural food bioactives as antineurodegeneration agents were also presented.
肠道-大脑连接可能由各种微生物分子介导，这些分子随后可以穿过肠道和血脑屏障并影响神经功能。模式识别受体 (PRR) 是肠道中重要的先天免疫蛋白。肠道微生物群与 PRR 协同作用是调节宿主-微生物信号和免疫稳态的新靶点，这可能涉及神经退行性疾病的发病机制。天然食物生物活性物质通过调节 PRR 改变修饰后的肠道微生物群或微生物群产生的代谢物的景观，从而通过免疫调节作用对神经退行性疾病赋予保护优势。在这篇综述中，我们讨论了天然食物生物活性物质对肠道微生物群的影响以及 PRR 在肠道-大脑通讯中的作用。我们专注于肠道微生物群和 PRR 作用背后天然生物活性化合物的神经保护机制。还介绍了天然食物生物活性物质作为抗神经退行性变剂的研究进展。
