针灸治疗癌症恶心呕吐患者：系统评价和荟萃分析方案。

Acupuncture for cancer patients with nausea and vomiting: A protocol for systematic review and meta-analysis.

机构信息

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, South Korea.

Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

出版信息

Medicine (Baltimore). 2023 Jan 20;102(3):e31478. doi: 10.1097/MD.0000000000031478.

DOI:10.1097/MD.0000000000031478

PMID:36701706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9857488/

Abstract

BACKGROUND

Nausea and vomiting are among the most common adverse effects experienced by cancer patients undergoing treatment worldwide. Their treatment with pharmacologic therapy can often be complicated by medication interactions and other unwanted side effects. The aim of this systematic review and meta-analysis protocol is to assess the effectiveness and safety of acupuncture therapy for treating nausea and vomiting in patients with cancer.

METHODS

Three electronic databases and 2 clinical registry platforms will be searched from inception to May 2022: the MEDLINE via PubMed, Embase via Ovid, the Cochrane Central Register of Controlled Trials via the Cochrane Library, the World Health Organisation International Clinical Trials Registry Platform, and National Institutes of Health Clinical trials.gov. Search terms will include nausea, vomiting, cancer, and acupuncture. Two researchers will independently select studies, extract data and assess the risk of bias. The primary outcome will be the incidence of nausea and/or vomiting or other validated outcome measures. Meta-analysis will be carried out using RevMan V.5.4. The quality of evidence from randomized clinical trials will be evaluated with the Grading of Recommendations Assessment, Development and Evaluation System tool.

RESULTS

The results will provide a high-quality synthesis of evidence for clinicians in the field of oncology.

CONCLUSION

The conclusion is expected to provide evidence to determine whether acupuncture is an effective and safe treatment for cancer patients with nausea and vomiting.

摘要

背景

恶心和呕吐是全球接受治疗的癌症患者最常见的不良反应之一。他们的药物治疗常常因药物相互作用和其他不良反应而变得复杂。本系统评价和荟萃分析方案的目的是评估针灸治疗癌症患者恶心和呕吐的有效性和安全性。

方法

从建库至 2022 年 5 月，我们将检索三个电子数据库和 2 个临床注册平台：PubMed 中的 MEDLINE、Ovid 中的 Embase、Cochrane 图书馆中的 Cochrane 中央对照试验注册库、世界卫生组织国际临床试验注册平台和美国国立卫生研究院临床试验.gov。检索词将包括恶心、呕吐、癌症和针灸。两名研究人员将独立选择研究、提取数据并评估偏倚风险。主要结局将是恶心和/或呕吐的发生率或其他经过验证的结局指标。使用 RevMan V.5.4 进行荟萃分析。将使用 Grading of Recommendations Assessment, Development and Evaluation System 工具评估随机临床试验的证据质量。