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Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation.

作者信息

Liu Haoran, Duan Chen, Yang Xiaoqi, Liu Jianhe, Deng Yaoliang, Tiselius Hans-Göran, Ye Zhangqun, Wang Tao, Xing Jinchun, Xu Hua

机构信息

Department of Urology, The First Affiliated Hospital of Anhui Medical University, 230000, Hefei, China.

Bio-X, Stanford University, 94303, Stanford, California, USA.

出版信息

Signal Transduct Target Ther. 2023 Jan 27;8(1):38. doi: 10.1038/s41392-022-01232-3.

DOI:10.1038/s41392-022-01232-3
PMID:36702833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9879973/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad90/9879973/1675501315f1/41392_2022_1232_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad90/9879973/1675501315f1/41392_2022_1232_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad90/9879973/1675501315f1/41392_2022_1232_Fig1_HTML.jpg

相似文献

[1]
Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation.

Signal Transduct Target Ther. 2023-1-27

[2]
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[3]
Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages.

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[4]
Pioglitazone decreased renal calcium oxalate crystal formation by suppressing M1 macrophage polarization via the PPAR-γ-miR-23 axis.

Am J Physiol Renal Physiol. 2019-7-1

[5]
Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature.

Front Immunol. 2021

[6]
Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation.

Eur J Pharmacol. 2021-10-15

[7]
Re: Sirtuin 3 Suppresses the Formation of Renal Calcium Oxalate Crystals through Promoting M2 Polarization of Macrophages.

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[8]
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[9]
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[10]
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引用本文的文献

[1]
Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation.

Clin Transl Med. 2025-8

[2]
Multiomics reveals metformin's dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention.

Sci Rep. 2025-7-2

[3]
Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B.

J Nanobiotechnology. 2025-5-27

[4]
Metformin hydrochloride improves hepatic glucolipid metabolism in diabetes progression through SIRT5-mediated ECHA desuccinylation.

Sci Rep. 2025-3-5

[5]
Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal.

Metab Brain Dis. 2024-11-25

[6]
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation.

Adv Sci (Weinh). 2024-12

[7]
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.

Urolithiasis. 2024-8-13

[8]
Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury.

J Transl Med. 2024-8-5

[9]
Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis.

Mol Med. 2024-6-25

[10]
The role and therapeutic potential of SIRTs in sepsis.

Front Immunol. 2024

本文引用的文献

[1]
Mechanism and application of metformin in kidney diseases: An update.

Biomed Pharmacother. 2021-6

[2]
Novel Insights into Crystal-Induced Kidney Injury.

Kidney Dis (Basel). 2018-6

[3]
Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease.

Front Immunol. 2018-3-29

[4]
M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development.

Sci Rep. 2016-10-12

[5]
Kidney stones.

Nat Rev Dis Primers. 2016-2-25

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