产妇分娩期抗生素使用与婴儿腹绞痛：有关联吗？
Maternal Intrapartum Antibiotic Administration and Infantile Colic: Is there a Connection?
作者信息
Leppälehto Elli, Pärtty Anna, Kalliomäki Marko, Löyttyniemi Eliisa, Isolauri Erika, Rautava Samuli
机构信息
Department of Paediatrics, University of Turku, Turku, Finland.
Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland.
出版信息
Neonatology. 2018;114(3):226-229. doi: 10.1159/000489991. Epub 2018 Jun 25.
BACKGROUND
The aetiology of infantile colic remains unknown. However, altered gut microbiota composition has been reported in children with the disorder.
OBJECTIVE
The objective of this study was to determine the associations between perinatal factors potentially affecting gut colonization and infantile colic.
METHODS
Altogether 48 infants with colic and 29 controls were selected from 2 ongoing clinical studies. Infants with and without colic were comparable with regard to their background characteristics.
RESULTS
A significant difference was detected in intrapartum antibiotic use and breastfeeding rates between infants with and without colic. The association between exposure to intrapartum antibiotics and infantile colic remained statistically significant after adjusting for potential confounding factors.
CONCLUSIONS
Since intrapartum antibiotic exposure may have an effect on early gut colonization, our finding is consistent with the association between aberrant early gut microbiota composition and development of colic. Antibiotic-exposed neonates may represent a novel target group for preventive intervention studies.
背景
婴儿腹绞痛的病因尚不清楚。然而，据报道，患有该疾病的儿童肠道微生物群组成发生了改变。
目的
本研究的目的是确定可能影响肠道定植的围产期因素与婴儿腹绞痛之间的关联。
方法
从2项正在进行的临床研究中选取了48例腹绞痛婴儿和29例对照婴儿。有腹绞痛和无腹绞痛的婴儿在背景特征方面具有可比性。
结果
有腹绞痛和无腹绞痛的婴儿在产时抗生素使用和母乳喂养率方面存在显著差异。在调整潜在混杂因素后，产时接触抗生素与婴儿腹绞痛之间的关联在统计学上仍然显著。
结论
由于产时接触抗生素可能对早期肠道定植有影响，我们的发现与异常的早期肠道微生物群组成与腹绞痛发展之间的关联一致。接触抗生素的新生儿可能是预防性干预研究的一个新目标群体。
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