Key Laboratory of Forest Protection of National Forestry and Grassland Administration, Ecology and Nature Conservation Institute, Chinese Academy of Forestry, National Bird Banding Center of China, Beijing, China.
State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.
Mol Biol Evol. 2023 Feb 3;40(2). doi: 10.1093/molbev/msad019.
Migratory birds play a critical role in the rapid spread of highly pathogenic avian influenza (HPAI) H5N8 virus clade 2.3.4.4 across Eurasia. Elucidating the timing and pattern of virus transmission is essential therefore for understanding the spatial dissemination of these viruses. In this study, we surveyed >27,000 wild birds in China, tracked the year-round migration patterns of 20 bird species across China since 2006, and generated new HPAI H5N8 virus genomic data. Using this new data set, we investigated the seasonal transmission dynamics of HPAI H5N8 viruses across Eurasia. We found that introductions of HPAI H5N8 viruses to different Eurasian regions were associated with the seasonal migration of wild birds. Moreover, we report a backflow of HPAI H5N8 virus lineages from Europe to Asia, suggesting that Europe acts as both a source and a sink in the global HPAI virus transmission network.
候鸟在高致病性禽流感（HPAI）H5N8 病毒 2.3.4.4 分支在欧亚大陆的快速传播中发挥了关键作用。因此，阐明病毒传播的时间和模式对于了解这些病毒的空间传播至关重要。在这项研究中，我们调查了中国的>27,000 只野生鸟类，自 2006 年以来跟踪了 20 种鸟类在中国的全年迁徙模式，并生成了新的高致病性禽流感 H5N8 病毒基因组数据。利用这个新数据集，我们调查了高致病性禽流感 H5N8 病毒在欧亚大陆的季节性传播动态。我们发现，高致病性禽流感 H5N8 病毒向不同欧亚地区的传入与野生鸟类的季节性迁徙有关。此外，我们报告了 HPAI H5N8 病毒谱系从欧洲到亚洲的回流，这表明欧洲既是全球 HPAI 病毒传播网络的源头也是汇点。
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