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基于生物膜的纳米结构和微结构负载水凝胶促进慢性伤口愈合。

Biomembrane-Based Nanostructure- and Microstructure-Loaded Hydrogels for Promoting Chronic Wound Healing.

机构信息

Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Department of Gastroenterology, Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.

出版信息

Int J Nanomedicine. 2023 Jan 19;18:385-411. doi: 10.2147/IJN.S387382. eCollection 2023.

DOI:10.2147/IJN.S387382
PMID:36703725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9871051/
Abstract

Wound healing is a complex and dynamic process, and metabolic disturbances in the microenvironment of chronic wounds and the severe symptoms they cause remain major challenges to be addressed. The inherent properties of hydrogels make them promising wound dressings. In addition, biomembrane-based nanostructures and microstructures (such as liposomes, exosomes, membrane-coated nanostructures, bacteria and algae) have significant advantages in the promotion of wound healing, including special biological activities, flexible drug loading and targeting. Therefore, biomembrane-based nanostructure- and microstructure-loaded hydrogels can compensate for their respective disadvantages and combine the advantages of both to significantly promote chronic wound healing. In this review, we outline the loading strategies, mechanisms of action and applications of different types of biomembrane-based nanostructure- and microstructure-loaded hydrogels in chronic wound healing.

摘要

伤口愈合是一个复杂和动态的过程，慢性伤口微环境中的代谢紊乱及其引起的严重症状仍然是需要解决的主要挑战。水凝胶的固有特性使它们成为有前途的伤口敷料。此外，基于生物膜的纳米结构和微结构（如脂质体、外泌体、膜包覆的纳米结构、细菌和藻类）在促进伤口愈合方面具有显著的优势，包括特殊的生物活性、灵活的药物装载和靶向性。因此，基于生物膜的纳米结构和微结构负载的水凝胶可以弥补各自的缺点，并结合两者的优点，显著促进慢性伤口愈合。在本文中，我们概述了不同类型的基于生物膜的纳米结构和微结构负载的水凝胶在慢性伤口愈合中的加载策略、作用机制和应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/d63e15078157/IJN-18-385-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/af6625a6015f/IJN-18-385-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/2e3b43b11af7/IJN-18-385-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/9b0504563539/IJN-18-385-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/b858d30c973e/IJN-18-385-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/ac668fe0ae43/IJN-18-385-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/c06f4802bf67/IJN-18-385-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/9304d2f4c51a/IJN-18-385-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/d63e15078157/IJN-18-385-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/af6625a6015f/IJN-18-385-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/2e3b43b11af7/IJN-18-385-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/9b0504563539/IJN-18-385-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/b858d30c973e/IJN-18-385-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/ac668fe0ae43/IJN-18-385-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/c06f4802bf67/IJN-18-385-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/9304d2f4c51a/IJN-18-385-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9259/9871051/d63e15078157/IJN-18-385-g0008.jpg

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引用本文的文献

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Towards Intelligent Wound Care: Hydrogel-Based Wearable Monitoring and Therapeutic Platforms.

Polymers (Basel). 2025-7-6

[2]
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[3]
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[4]
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本文引用的文献

[1]
Self-Assembled Nano-Peptide Hydrogels with Human Umbilical Cord Mesenchymal Stem Cell Spheroids Accelerate Diabetic Skin Wound Healing by Inhibiting Inflammation and Promoting Angiogenesis.

Int J Nanomedicine. 2022

[2]
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy.

Cell Oncol (Dordr). 2022-6

[3]
VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis.

Acta Biomater. 2022-7-15

[4]
A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing.

Biomater Adv. 2022-2

[5]
Mechanism and application of exosomes in the wound healing process in diabetes mellitus.

Diabetes Res Clin Pract. 2022-5

[6]
Nitric oxide-releasing biomaterials for promoting wound healing in impaired diabetic wounds: State of the art and recent trends.

Biomed Pharmacother. 2022-5

[7]
Polydopamine Decorated Microneedles with Fe-MSC-Derived Nanovesicles Encapsulation for Wound Healing.

Adv Sci (Weinh). 2022-5

[8]
Electrosprayed cefazolin-loaded niosomes onto electrospun chitosan nanofibrous membrane for wound healing applications.

J Biomed Mater Res B Appl Biomater. 2022-8

[9]
Engineering Robust Ag-Decorated Polydopamine Nano-Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing.

Adv Sci (Weinh). 2022-4

[10]
Microwave-Assisted Physically Cross-Linked Chitosan-Sodium Alginate Hydrogel Membrane Doped with Curcumin as a Novel Wound Healing Platform.

AAPS PharmSciTech. 2022-2-11

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