基于双向刺激的脊髓损伤康复动态模型构建及其在脑机接口康复中的应用
Construction of the dynamic model of SCI rehabilitation using bidirectional stimulation and its application in rehabilitating with BCI.
作者信息
Cui Zhengzhe, Lin Juan, Fu Xiangxiang, Zhang Shiwei, Li Peng, Wu Xixi, Wang Xue, Chen Weidong, Zhu Shiqiang, Li Yongqiang
机构信息
School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Cogn Neurodyn. 2023 Feb;17(1):169-181. doi: 10.1007/s11571-022-09804-3. Epub 2022 Apr 27.
UNLABELLED
Patients with complete spinal cord injury have a complete loss of motor and sensory functions below the injury plane, leading to a complete loss of function of the nerve pathway in the injured area. Improving the microenvironment in the injured area of patients with spinal cord injury, promoting axon regeneration of the nerve cells is challenging research fields. The brain-computer interface rehabilitation system is different from the other rehabilitation techniques. It can exert bidirectional stimulation on the spinal cord injury area, and can make positively rehabilitation effects of the patient with complete spinal cord injury. A dynamic model was constructed for the patient with spinal cord injury under-stimulation therapy, and the mechanism of the brain-computer interface in rehabilitation training was explored. The effects of the three current rehabilitation treatment methods on the microenvironment in a microscopic nonlinear model were innovatively unified and a complex system mapping relationship from the microscopic axon growth to macroscopic motor functions was constructed. The basic structure of the model was determined by simulating and fitting the data of the open rat experiments. A clinical rehabilitation experiment of spinal cord injury based on brain-computer interface was built, recruiting a patient with complete spinal cord injury, and the rehabilitation training and follow-up were conducted. The changes in the motor function of the patient was simulated and predicted through the constructed model, and the trend in the motor function improvement was successfully predicted over time. This proposed model explores the mechanism of brain-computer interface in rehabilitating patients with complete spinal cord injury, and it is also an application of complex system theory in rehabilitation medicine.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s11571-022-09804-3.
未标注
完全性脊髓损伤患者在损伤平面以下运动和感觉功能完全丧失，导致损伤区域神经通路功能完全丧失。改善脊髓损伤患者损伤区域的微环境，促进神经细胞轴突再生是具有挑战性的研究领域。脑机接口康复系统与其他康复技术不同。它可以对脊髓损伤区域施加双向刺激，并能对完全性脊髓损伤患者产生积极的康复效果。构建了脊髓损伤患者在刺激治疗下的动态模型，探讨了脑机接口在康复训练中的机制。创新性地统一了三种当前康复治疗方法在微观非线性模型中对微环境的影响，并构建了从微观轴突生长到宏观运动功能的复杂系统映射关系。通过模拟和拟合公开的大鼠实验数据确定了模型的基本结构。建立了基于脑机接口的脊髓损伤临床康复实验，招募了一名完全性脊髓损伤患者，并进行了康复训练和随访。通过构建的模型模拟和预测了患者运动功能的变化，并成功预测了运动功能随时间改善的趋势。该模型探讨了脑机接口在完全性脊髓损伤患者康复中的机制，也是复杂系统理论在康复医学中的应用。
补充信息
在线版本包含可在10.1007/s11571-022-09804-3获取的补充材料。
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