Department of Respiratory & Critical Care Medicine, The Second People's Hospital of Yibin, Yibin, 644000, China.
Per Med. 2023 Mar;20(2):167-173. doi: 10.2217/pme-2022-0104. Epub 2023 Jan 27.
To study the connection between lncRNA plasma expression and clinical characteristics as well as prognoses of patients. Sixty lung adenocarcinoma (LUAD) patients and 60 healthy adults participated in this research. LncRNA expression was detected by quantitative real-time PCR and the relationships between lncRNA plasma expression and patient prognosis and clinical characteristics were analyzed. LncRNA was highly expressed in LUAD tissues and plasma (p < 0.05). Receiver operating characteristic curve analysis indicated the diagnostic value of lncRNA in LUAD (p < 0.0001). Higher plasma lncRNA expression indicated worse patient prognoses (p < 0.05). Plasma lncRNA level was also closely related to tumor differentiation and tumor-node-metastasis stage (p < 0.05). Plasma lncRNA may be a potential biomarker for LUAD diagnosis and prognosis.
研究长链非编码 RNA（lncRNA）在血浆中的表达与肺癌患者临床特征和预后的关系。本研究纳入 60 例肺腺癌（LUAD）患者和 60 例健康成年人。采用实时荧光定量 PCR 检测 lncRNA 表达，分析 lncRNA 血浆表达与患者预后和临床特征的关系。lncRNA 在 LUAD 组织和血浆中高表达（p<0.05）。受试者工作特征曲线分析表明 lncRNA 对 LUAD 具有诊断价值（p<0.0001）。血浆 lncRNA 表达水平越高，患者预后越差（p<0.05）。血浆 lncRNA 水平还与肿瘤分化和肿瘤-淋巴结-转移分期密切相关（p<0.05）。血浆 lncRNA 可能是 LUAD 诊断和预后的潜在生物标志物。
