Uprety Ananta, Pantha Binod, Karki Lochan, Nepal Suresh Prasad, Khadka Milan
Department of Medicine, Bir Hospital, Kathmandu, Nepal.
Department of General Practice, Bir Hospital, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2019 Sep-Oct;57(219):340-343. doi: 10.31729/jnma.4569.
Organophosphorous poisoning is a common problem prevalent in Nepal. Intermediate syndrome is a common clinical feature seen among the patients those have ingested poison. There is a scarcity of data related to intermediate syndrome and other general complications in patients with organophosphorous poisoning in context of Nepal. This study was carried out to observe the prevalence of intermediate syndrome and the general complications of oraganophosphorus poisoning among admitted patients in a tertiary care hospital.
This was a descriptive cross-sectional study conducted at a tertiary care hospital from April 2008 to June 2009 after ethical approval was from Institiutional Review Board of tertiary care hospital. Forty four patients with history of ingestion of organophosphorus poisoning within 24 hours were included in our study through convenience sampling. Clinical examinations were done to look for Intermediate syndrome. Data was entered in Statistical Package for Social Sciences and point estimate at 95% of CI was calculated along with frequency and proportion for binary data.
Out of 44 patients, features of intermediate syndrome were seen in 40 (90.9%) at 95% of CI (84.2-97.6) patients in the study. The frequency of intermediate syndrome signs like weakness of neck flexion, inability to sit up and swallowing difficulty were seen among the patients. Complications like pneumonia 4 (9.09%), hyponatremia 3 (6.8%), hypokalemia 1 (2.27%) and bradycardia 1 (2.27%) were seen in the study. Mortality seen in the study was 2 (4.5%) among the admitted patients.
Prevalence of intermediate syndrome was higher compared to other studies done in similar settings. Complications like pneumonia, hyponatremia, hypokalemia and bradycardia were seen among the patients.
有机磷中毒是尼泊尔普遍存在的一个常见问题。中间综合征是摄入毒物的患者中常见的临床特征。在尼泊尔，关于有机磷中毒患者中间综合征及其他一般并发症的数据稀缺。本研究旨在观察一家三级护理医院收治患者中中间综合征的患病率以及有机磷中毒的一般并发症。
这是一项描述性横断面研究，于2008年4月至2009年6月在一家三级护理医院进行，研究获得了该三级护理医院机构审查委员会的伦理批准。通过方便抽样，我们纳入了44例在24小时内有有机磷中毒摄入史的患者。进行临床检查以寻找中间综合征。数据录入社会科学统计软件包，并计算95%置信区间的点估计值以及二元数据的频率和比例。
在44例患者中，研究发现40例（90.9%）在95%置信区间（84.2 - 97.6）的患者出现中间综合征特征。患者中出现了如颈部屈曲无力、无法坐起和吞咽困难等中间综合征体征的频率。研究中还发现了并发症，如肺炎4例（9.09%）、低钠血症3例（6.8%）、低钾血症1例（2.27%）和心动过缓1例（2.27%）。研究中收治患者的死亡率为2例（4.5%）。
与在类似环境中进行的其他研究相比，中间综合征的患病率更高。患者中出现了如肺炎、低钠血症、低钾血症和心动过缓等并发症。
