三甲医院有机磷中毒病例的血清肌酸激酶水平：一项描述性横断面研究。

Mean Serum Creatine Kinase among Organophosphate Poisoning Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

机构信息

Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.

Department of Pharmacology, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2022 Oct 1;60(254):881-883. doi: 10.31729/jnma.7692.

DOI:10.31729/jnma.7692

PMID:36705158

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9924919/

Abstract

INTRODUCTION

Major cases of poisoning are associated with organophosphates. Cholinergic effects and an intermediate phase seen with organophosphate poisoning may implicate myopathy. Creatine kinase is a marker of muscle tissue damage. This study aimed to find out the mean serum creatine kinase among organophosphate poisoning cases in a tertiary care centre.

METHODS

A descriptive cross-sectional study was carried out among organophosphate poisoning cases in a tertiary care hospital from 13 October 2017 to 30 March 2018. Ethical approval was taken from the Institutional Review Committee [Reference number: 117(6-11-E) 2/074/075]. Blood samples were assayed for serum acetylcholinesterase in the pharmacology laboratory and for serum creatine kinase and lactate dehydrogenase in the biochemistry laboratory. Low serum acetylcholinesterase was taken as the basis for the establishment of organophosphate poisoning. A convenience sampling technique was used. Point estimate and 95% Confidence Interval were calculated.

RESULTS

Among 103 organophosphate poisoning cases, the mean serum creatine kinase was 931.35±446.60 IU/l (845.10-1017.60, 95% Confidence Interval).

CONCLUSIONS

The mean serum creatine kinase level among organophosphate poisoning cases was higher than in other studies done in similar settings.

KEYWORDS

acetylcholinesterase; creatine kinase; organophosphate poisoning; rhabdomyolysis.

摘要

简介

重大中毒病例与有机磷有关。有机磷中毒时出现的胆碱能效应和中间期可能提示肌病。肌酸激酶是肌肉组织损伤的标志物。本研究旨在了解三级护理中心有机磷中毒病例的血清肌酸激酶均值。

方法

对 2017 年 10 月 13 日至 2018 年 3 月 30 日期间三级医院的有机磷中毒病例进行描述性横断面研究。机构审查委员会批准了该研究[参考编号：117(6-11-E)2/074/075]。在药理学实验室检测血清乙酰胆碱酯酶，在生物化学实验室检测血清肌酸激酶和乳酸脱氢酶。低血清乙酰胆碱酯酶被视为建立有机磷中毒的依据。采用方便抽样技术。计算点估计值和 95%置信区间。