维生素 D 缺乏症患者的自身免疫性甲状腺疾病：三级护理中心生物化学系的描述性横断面研究。

Autoimmune Thyroid Disease in Patients with Hypovitaminosis D in Department of Biochemistry of a Tertiary Care Centre: A Descriptive Cross-sectional Study.

机构信息

Department of Biochemistry, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.

Department of Biochemistry, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2022 Jul 1;60(251):600-603. doi: 10.31729/jnma.7493.

DOI:10.31729/jnma.7493

PMID:36705201

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9297365/

Abstract

INTRODUCTION

Autoimmune thyroid disease is characterised by the generation of autoantibodies against self-antigens such as thyroid peroxidase, thyroglobulin, and thyroid-stimulating hormone receptor. Recent studies have implicated the role of hypovitaminosis D to immune dysfunction, failure of self-tolerance and generation of autoantibodies. This study aimed to find out the prevalence of autoimmune thyroid disease among hypovitaminosis D patients in a tertiary care centre.

METHODS

A descriptive cross-sectional study was conducted among participants between the ages of 18 years to 65 years who visited the Department of Biochemistry of a tertiary care centre between the periods of July 2018 to December 2019. The study was initiated after receiving ethical approval from the Institutional Review Committee (Reference number: 42,8/074/075-IRC). Data was collected using a self-administered questionnaire followed by anthropometric measurement and blood collection. Thyroid hormone, thyroid peroxidase antibody and 25-hydroxy vitamin D were measured by chemiluminescence technique. Convenience sampling was used. Point estimate and 95% Confidence Interval were calculated.

RESULTS

Among 83 patients, 39 (46.98%) (42.32-51.63, 95% Confidence Interval) had autoimmune thyroid disease.

CONCLUSIONS

The prevalence of autoimmune thyroid disease among patients with hypovitaminosis D was similar to studies conducted in comparable settings.

KEYWORDS

autoimmune diseases; prevalence; thyroid; vitamin D.

摘要

简介

自身免疫性甲状腺疾病的特征是针对自身抗原（如甲状腺过氧化物酶、甲状腺球蛋白和促甲状腺激素受体）产生自身抗体。最近的研究表明，维生素 D 缺乏与免疫功能障碍、自身耐受失败和自身抗体产生有关。本研究旨在探讨三级保健中心维生素 D 缺乏患者自身免疫性甲状腺疾病的患病率。

方法

在 2018 年 7 月至 2019 年 12 月期间，在一家三级保健中心的生物化学科就诊的 18 至 65 岁参与者中进行了一项描述性横断面研究。在获得机构审查委员会（参考编号：42,8/074/075-IRC）的伦理批准后，开始了这项研究。使用自我管理问卷收集数据，随后进行人体测量和血液采集。甲状腺激素、甲状腺过氧化物酶抗体和 25-羟维生素 D 采用化学发光技术测量。使用便利抽样。计算了点估计值和 95%置信区间。