Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
J Infect Dis. 2023 Jun 15;227(12):1343-1347. doi: 10.1093/infdis/jiad018.
From 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission studies (enrolling April 2020 to January 2022) with rapid enrollment and specimen collection for 14 days, 61% (43/70) of primary cases had culturable virus detected ≥6 days post-onset. Risk of secondary infection among household contacts tended to be greater when primary cases had culturable virus detected after onset. Regardless of duration of culturable virus, most secondary infections (70%, 28/40) had serial intervals <6 days, suggesting early transmission. These data examine viral culture as a proxy for infectiousness, reaffirm the need for rapid control measures after infection, and highlight the potential for prolonged infectiousness (≥6 days) in many individuals.
从 2 项严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 家庭传播研究（招募时间为 2020 年 4 月至 2022 年 1 月）中可以看出，在快速入组和 14 天内采集样本的情况下，70%（43/70）的首发病例在发病后≥6 天检测到可培养病毒。当首发病例在发病后检测到可培养病毒时，家庭接触者继发感染的风险往往更大。无论可培养病毒的持续时间如何，大多数继发感染（70%，28/40）的间隔时间<6 天，提示早期传播。这些数据通过病毒培养来检测传染性，再次强调了在感染后需要快速采取控制措施，并且突出了许多人具有潜在的传染性延长（≥6 天）。
