From the Institute of Biomedicine, Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
the Institute of Clinical Medicine and Biostatistics, University of Turku, Turku, Finland.
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):218-226. doi: 10.1097/MPG.0000000000003659. Epub 2022 Nov 23.
To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter their body fat percentage.
Women (n = 439) were double-blindly randomized into 4 intervention groups: fish oil+placebo, probiotics+placebo, probiotics+fish oil, and placebo+placebo (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid, probiotics: Lacticaseibacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 1010 colony-forming units each). The intervention lasted from early pregnancy until 6 months postpartum. Children's (n = 330) growth data (height, weight, head circumference), a secondary outcome of the trial, were evaluated at birth, 3, 6, 12, and 24 months of age and compared to Finnish growth charts. Body fat percentage was measured with air displacement plethysmography (24 months). Logistic regression and general linear models were used to analyze the data.
Probiotics+placebo [weight-for-height% adj. Odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.14-0.95] and probiotics+fish oil [weight-for-age standard deviation score (SD-score) adj. OR = 0.22, 95% CI = 0.07-0.71] associated with lower overweight odds in 24-month-old children compared to placebo+placebo. Results remained essentially the same, when probiotics' main effect (combined probiotics+placebo and probiotics+fish oil) was estimated; that is, lower overweight odds (weight-for-height% adj. OR = 0.48, 95% CI = 0.25-0.95 and weight-for-age SD-score adj. OR = 0.42, 95% CI = 0.20-0.88) compared to non-probiotics. No fish oil main effect (combined fish oil+placebo and probiotics+fish oil) was seen. The intervention did not influence body fat percentage.
The administration of probiotics solely and in combination with fish oil during pregnancy to women with overweight or obesity lowered the overweight odds of their 24-month-old children.
评估在超重或肥胖的孕妇中进行鱼油和/或益生菌干预是否会影响其 24 个月大的孩子超重的趋势，并改变他们的体脂百分比。
将 439 名女性随机分为 4 个干预组：鱼油+安慰剂、益生菌+安慰剂、益生菌+鱼油和安慰剂+安慰剂（鱼油：1.9 克二十二碳六烯酸和 0.22 克二十碳五烯酸，益生菌：鼠李糖乳杆菌 HN001 和动物双歧杆菌亚种。 lactis 420，每个 1010 个菌落形成单位）。干预从妊娠早期持续到产后 6 个月。在出生时、3 个月、6 个月、12 个月和 24 个月评估了儿童（n=330）的生长数据（身高、体重、头围），这是该试验的次要结果，并与芬兰生长图表进行了比较。使用空气置换体描记术（24 个月）测量体脂百分比。使用逻辑回归和一般线性模型分析数据。
与安慰剂+安慰剂相比，益生菌+安慰剂[体重身高%调整比值比（OR）=0.36，95%置信区间（CI）=0.14-0.95]和益生菌+鱼油[体重年龄标准偏差评分（SD-评分）调整 OR =0.22，95%CI=0.07-0.71]与 24 个月大儿童超重的几率较低相关。当估计益生菌的主要作用（合并益生菌+安慰剂和益生菌+鱼油）时，结果基本保持不变，即超重的几率较低（体重身高%调整 OR=0.48，95%CI=0.25-0.95 和体重年龄 SD-评分调整 OR=0.42，95%CI=0.20-0.88）与非益生菌相比。未观察到鱼油的主要作用（合并鱼油+安慰剂和益生菌+鱼油）。该干预措施并未影响体脂百分比。
在超重或肥胖的孕妇中单独或联合使用鱼油和益生菌进行干预可降低其 24 个月大的孩子超重的几率。
