Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong, China.
Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Folia Microbiol (Praha). 2024 Feb;69(1):1-15. doi: 10.1007/s12223-023-01087-3.
Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the first gut flora to colonize the early stages of life. Intestinal flora is closely related to health, and dysbiosis of intestinal flora, especially Bifidobacteria, has been found in a variety of diseases. Numerous studies have shown that in addition to maintaining intestinal homeostasis, Bifidobacteria may be involved in diseases covering all parts of the body, including the nervous system, respiratory system, genitourinary system and so on. This review collects evidence for the variation of Bifidobacteria in typical diseases among various systems, provides mild and effective therapeutic options for those diseases that are difficult to cure, and moves Bifidobacteria from basic research to further clinical applications.
双歧杆菌作为一种严格厌氧的革兰氏阳性菌，广泛分布于肠道、阴道和口腔，是定植于生命早期阶段的最早的肠道菌群之一。肠道菌群与健康密切相关，肠道菌群失调，尤其是双歧杆菌，已在多种疾病中被发现。大量研究表明，双歧杆菌除了维持肠道内环境平衡外，还可能与涉及全身各个部位的疾病有关，包括神经系统、呼吸系统、泌尿生殖系统等。本综述收集了双歧杆菌在各系统中典型疾病变化的证据，为那些难以治愈的疾病提供了温和有效的治疗选择，并将双歧杆菌从基础研究推向了进一步的临床应用。
