Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Lasers Med Sci. 2023 Jan 28;38(1):56. doi: 10.1007/s10103-022-03661-6.
Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic airway inflammation and remodeling and lung parenchymal inflammation and destruction, which result in many pulmonary and extrapulmonary manifestations. The anti-inflammatory effect of photobiomodulation (PBM) has been reported in previous studies. This review was conducted to evaluate the direct effect of PBM on lung inflammation in COPD. The other effects of PBM on modulation of peripheral and respiratory muscle metabolism and angiogenesis in lung tissues were also discussed. The databases of PubMed, Cochrane Library, and Google Scholar were searched to find the relevant studies. Keywords included PBM and related terms, COPD-related signs, and lung inflammation. A total of 12 articles were selected and reviewed in this study. Based on the present review, PBM is helpful in reducing lung inflammation through decreasing the inflammatory cytokines and chemokines at multiple levels and increasing anti-inflammatory cytokines. In addition, PBM also improves both peripheral and respiratory muscle metabolism and promote angiogenesis. This review demonstrated that PBM is a promising adjunctive treatment modality for COPD management which merits further validation.
慢性阻塞性肺疾病（COPD）是一种以慢性气道炎症和重塑以及肺实质炎症和破坏为特征的疾病，导致许多肺内和肺外表现。先前的研究已经报道了光生物调节（PBM）的抗炎作用。本综述旨在评估 PBM 对 COPD 中肺炎症的直接作用。还讨论了 PBM 对调节肺组织外周和呼吸肌代谢以及血管生成的其他作用。在 PubMed、Cochrane Library 和 Google Scholar 数据库中搜索了相关研究。关键词包括 PBM 及相关术语、COPD 相关征象和肺炎症。本研究共选择并回顾了 12 篇文章。基于本综述，PBM 通过在多个层面减少炎症细胞因子和趋化因子，增加抗炎细胞因子，有助于减轻肺炎症。此外，PBM 还改善外周和呼吸肌代谢，促进血管生成。本综述表明，PBM 是 COPD 管理的一种有前途的辅助治疗方式，值得进一步验证。
