NeoMedLight, Lyon, France.
Département de Radiothérapie, Institut de Cancérologie de La Loire - Lucien Neuwirth, 42270, St Priest en Jarez, France.
BMC Oral Health. 2021 Apr 29;21(1):220. doi: 10.1186/s12903-021-01574-4.
Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for the treatment of such oral toxicity. The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM prevention and treatment, and more precisely to focus on the effect of PBM on tumor and healthy cells.
MEDLINE/PubMed, and google scholar were searched electronically. Selected studies were focusing on PBM effects on tumor and healthy cells.
PBM interactions with the tissue and additional mechanism in OM therapy were detailed in this review. Moreover, this review highlighted a controversy about the carcinogenic effect of PBM. Indeed, Many studies reported that PBM could enhance malignant cell proliferation; suggesting that PBM would have no protective effect. In addition to acting on cancer cells, PBM may damage healthy cells.
More prospective studies are needed to assess the effect of PBM on cancer cells in order to improve its use for OM prevention and treatment.
口腔黏膜炎（OM）是癌症患者在接受放化疗时经历的一种严重并发症。光生物调节（PBM）疗法，也称为低水平激光疗法，已越来越多地用于治疗这种口腔毒性。本综述的目的是讨论光生物调节（PBM）在预防和治疗 OM 方面的机制，更具体地说，是要关注 PBM 对肿瘤和健康细胞的影响。
通过电子方式在 MEDLINE/PubMed 和谷歌学术上进行搜索。选择的研究重点是 PBM 对肿瘤和健康细胞的影响。
本综述详细介绍了 PBM 与组织的相互作用和 OM 治疗中的其他机制。此外，本综述还强调了 PBM 致癌作用的争议。事实上，许多研究报告称 PBM 可以增强恶性细胞的增殖；表明 PBM 不会有保护作用。除了作用于癌细胞外，PBM 还可能损伤健康细胞。
需要更多的前瞻性研究来评估 PBM 对癌细胞的影响，以便改进其在 OM 预防和治疗中的应用。
