肝病中的细胞外囊泡及其作为生物标志物和治疗靶点的潜力。
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets.
作者信息
Szabo Gyongyi, Momen-Heravi Fatemeh
机构信息
Department of Medicine, University of Massachusetts Medical School, LRB208, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
出版信息
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):455-466. doi: 10.1038/nrgastro.2017.71. Epub 2017 Jun 21.
Abstract
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics.
摘要
细胞外囊泡（EVs）是源自肝脏中不同细胞的膜性囊泡。EVs在包括酒精性肝病、非酒精性脂肪性肝病、病毒性肝炎和肝细胞癌在内的肝脏疾病中的病理生理作用日益受到认可。EVs通过其携带的物质，可以在肝脏中的不同细胞类型之间以及器官之间提供通讯。EVs正被探索作为疾病的生物标志物，并且也可能代表治疗靶点和治疗递送载体。在此，我们综述了在理解EVs在肝脏疾病中的作用方面的进展，并讨论了它们在生物标志物发现和治疗中的应用。
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