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儿童生长监测的过去、现在和未来:临床遗传学的综述和入门

The past, present, and future of child growth monitoring: A review and primer for clinical genetics.

机构信息

Rare Disease Institute, Children's National Research and Innovation Campus, Washington, District of Columbia, USA.

The Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital, Washington, District of Columbia, USA.

出版信息

Am J Med Genet A. 2023 Apr;191(4):948-961. doi: 10.1002/ajmg.a.63102. Epub 2023 Jan 28.

Abstract

Child growth measurements are critical vital signs to track, with every individual child growth curve potentially revealing a story about a child's health and well-being. Simply put, every baby born requires basic building blocks to grow and thrive: proper nutrition, love and care, and medical health. To ensure that every child who is missing one of these vital aspects is identified, growth is traditionally measured at birth and each well-child visit. While the blue and pink growth curves appear omnipresent in pediatric clinics, it is surprising to realize that their use only became standard of care in 1977 when the National Center for Health Statistics (NCHS) adopted the growth curve as a clinical tool for health. Behind this practice lies a socioeconomically, culturally, and politically complex interplay of individuals and institutions around the world. In this review, we highlight the often forgotten past, current state of practice, and future potential of this powerful clinical tool: the growth reference chart, with a particular focus on clinical genetics practice. The goal of this article is to understand ongoing work in the field of anthropometry (the scientific study of human measurements) and its direct impact on modern pediatric and genetic patient care.

摘要

儿童生长测量是关键的生命体征指标,每个儿童的生长曲线都可能揭示其健康和幸福状况的故事。简单来说,每个新生儿都需要基本的生长和发育要素:适当的营养、关爱和医疗保健。为了确保识别出每一个缺失这些关键要素的儿童,传统上会在出生时和每次儿童健康检查时测量生长情况。虽然蓝色和粉色的生长曲线在儿科诊所中随处可见,但令人惊讶的是,直到 1977 年,国家健康统计中心(NCHS)将生长曲线作为健康的临床工具采用后,其使用才成为护理标准。这一实践背后是全球个人和机构之间在社会经济、文化和政治方面复杂的相互作用。在这篇综述中,我们重点介绍了这一强大临床工具(生长参考图表)的过去常常被遗忘的历史、当前实践状态和未来潜力,特别关注临床遗传学实践。本文的目的是了解人体测量学(人类测量的科学研究)领域的持续工作及其对现代儿科和遗传患者护理的直接影响。

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